Tumor destruction

Systemic targeting of pDNA and siRNA polyplexes has been demonstrated in several animal models. In continuation of the work with localized antiproliferative and immunostimulatory poly(I C) RNA, intravenous systemic delivery of EGER-targeted PEG-modified polyplexes were successfully used for human carcinoma treatment in mice [225]. The therapeutic effect was most pronounced when intravenous delivery of poly(I C) polyplexes was followed by intraperitoneal injection of peripheral blood mononuclear cells [226]. This induced the complete cure of SCID mice with pre-established disseminated EGFR-overexpressing tumors, without adverse toxic effects. Due to the chemokines produced by the internalized poly (I C) in the tumor cells, the immune cells home to the tumors of the treated animal and contribute to the tumor destruction. 

It has been shown that hyperthermia (e.g., by resistive heating of the electrode) plays no role in the tumor destruction.38... 

No effect of the nature of metallic electrodes was found on the tumor destruction,7 38 39 e.g., silver and tungsten electrodes gave results similar to platinum 7 this also means that a slight anodic dissolution of platinum that might occur during the ECT experiment is not responsible for the necrosis of the tumor.7... 

Griffin and coworkers (U.K.) reported work on ECT of mammary carcinoma in mice.67 Tumor destruction was found to be significantly greater, for a given charge, when anode was implanted in the tumor with cathode outside it. The results demonstrated a linear relationship between the volume of tumor regression induced and the quantity of electric charge passed. 

Castano AP, Demidova TN, Hamblin MR (2005) Mechanisms in photodynamic therapy Part three - Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. Photodiagnosis and Photodynamic Therapy 2 91-106. 

IL-2+ LAK cell or tumor infiltrating lymphocyte tumor destruction rodent and human... 

Gordon EM, Chan MT, Geraldino N, Lopez FF, et al. 2007. Le morte du tumour Histological features of tumor destruction in chemo-resistant cancers following intravenous infusions of pathotropic nanoparticles bearing therapeutic genes. Int J Oncol. 30 1297-1307. 

Since the a particles travel only 10 tim or less distance, the B nucleii-localized cancer cells are destroyed selectively. However, the estimated amount of B nucleii needed for tumor destruction is approximately 10 atoms or 10 30 tg B/g tumor. Therefore, the polyhedral borane and carborane-confaining biomolecules are found to be ideal for use in BNCT... 

The NS used in this work are designed to be excited with lasers in the NIR region, which have excellent transmittance through tissue. To date these NS have been added to cells for tumor destruction through plasmonic heating, but as demonstrated above they also have excellent potential for use in spectroscopic investigations of... 

The mechanism of action of yeast polysaccharides differed from that of bacterial polysaccharides. For example, some of the bacterial polysaccharides caused extreme hemorrhagic reaction within the tumors, whereas zymosan did not produce hemorrhage in the tumors. Differ and coworkers133 and Arndt and coworkers224 found that hydroglucan did not elicit Schwartzmann reaction in the skin of mice in which it induced tumor destruction. The histological changes, indicative of an alarm reaction, that were produced as a result of treatment... 

B.W. Henderson, S.M. Waldow, T.S. Mang, W.R. Potter, P.B. Malone, T.J. Dougherty (1985). Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy. Cancer Res., 45, 572-576. 

J.S. Nelson, L.H. Liaw, A. Orenstein, W.G. Roberts, M.W. Berns (1988). Mechanism of tumor destruction following photodynamic therapy with hematoporphyrin derivative, chlorin, and phthalocyanine. J. Natl. Cancer Inst., 80, 1599-1605. 

The Ce6 is loealised in lisosomes where it induces damage after irradiation. The Ce6 derivative agents, including the mono-L-aspartyl chlorine e6 (Ace6), the diaspartyl Ce6, the monoseryl Ce6 and other derivative amino acids, which are more lipophilic, are better retained by the tumors and therefore induce a better tumor destruction than the Ce6 agent itself [41,42]. 

B.W. Henderson, T.J. Dougherty, P.B. Malone (1984). Studies on the mechanism of tumor destruction by photoradiation therapy. Prog. Clin. Biol. Res., 170, 601-612. 

Photodynamic therapy (PDT) is currently undergoing intensive clinical investigations as an adjunctive treatment for malignant brain tumors. PDT is based on a higher accumulation of a photosensitiser in malignant over normal tissue with low systemic toxicity [9-11]. Subsequent light activation induces photooxidation followed by selective tumor destruction via vascular or direct cellular mechanisms [12-14]. 

Selection of candidates must take account of the significant fraction of patients whose tumors lack MHC class I [106, 107] or are so poorly differentiated and immunogenic that tumor-specific immunotherapy is doomed to failure. Under appropriate immunoregulatory stimuli, such as those obtained by combining the effects of IL-12 and IL-15 [59], granulocytes may lead to tumor destruction and cooperate in antitumor immune memory reactions to prevent relapses. 

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