Gene therapeutics

Basic Gene Therapeutic Approaches for Viral Diseases.267... 

Gene Therapeutic Strategies that Act via Host Immune Effector Mechanisms.283... 

There are three principal gene therapeutic approaches for viral diseases. First, several genes that inhibit virus replication have been developed. This approach has been termed intracellular immunization (Baltimore 1988). Second, genetic approaches... 

To onr knowledge, all antiviral gene-therapeutic strategies tested in clinical trials to date target HIV-infection. 

Smith, J., Zhang, Y.L., and Niven, R., Toward development of non-viral gene therapeutics, Advanced Drug Delivery Reviews, 1997, 26, 135-150. 

Pdaro, A.M., and Serabian, M.A. (1999) Preclinical development strategies for novel gene therapeutic products. Toxicol. Pathol. 27, 4-7. 

The advances in genetic and cellular research have allowed development of cell and gene therapeutic strategies for treating wide-ranging medical conditions. The field... 

Zhdanov, R.I., Sviridov, V., Podobed, O.V., et al. (1998). In vitro and in vivo functional gene transfer with cholesteroyl polyethylen/propylen/imines. In 6th Symposium on Gene Therapy Towards to Gene Therapeutics, MDC, Berlin-Buch, May 4-6, 101, Abstract. 

Wolff JA. 1994. Gene Therapeutics Methods and Applications of Direct Gene Transfer. Birkhauser, Boston, MA. 

Bai J, Banda N, Lee NS, Rosi J, Akkina R, RNA based anti-HIY-1 gene therapeutic constructs in SCID-hu mouse model, Mol. Ther., 6 770-782, 2002. 

To derive an informed decision in the selection of an appropriate gene therapeutic vehicle for the treatment of a specific neurologic disease, the following must be considered vector capacity, tropism, genome maintenance, vector-mediated transgene expression duration and levels, and safety profile. 

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