Tumor growth suppression

Schaffert D, Kiss M, Rodl W, Shir A, Levitzki A, Ogris M, Wagner E (2011) Poly(I C)-mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear polyethylenimine as carrier. Pharm Res 28 731-741... 

Tsuzuki,T.,Tokuyama,Y., Igarashi, M., and Miyazawa,T. 2004. Tumor growth suppression by alpha-eleostearic acid, a linolenic acid isomer with conjugated triene system, via lipid peroxidation. Carcinogenesis, 25,1-9. 

The relative importance of the de novo and salvage pathways is unclear. However, the severe symptoms of hereditary HGPRT deficiency indicate that the purine salvage pathway is vitally important. In addition, investigations of purine nucleotide synthesis inhibitors for treating cancer indicate that both pathways must be inhibited for significant tumor growth suppression. 

Atelocollagen siRNA Tumor growth suppression FGF-4 Mice/intratumorally [108]... 

Tsuzuki, T, Y. Tokuyama, M. Igarashi, and T. Miyazawa. Tumor Growth Suppression by... 

Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB (2007) Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res... 

The growth and spread of thyroid carcinoma are stimulated by TSH. An important component of thyroid carcinoma management is the use of LT4 to suppress TSH secretion. Early in therapy, patients receive the lowest LT4 dose sufficient to fully suppress TSH to undetectable levels. Controlled trials show that suppressive LT4 therapy reduces tumor growth and improves survival. 

LT4 doses sufficient to suppress tumor growth may result in a suppressed TSH and mild hyperthyroidism. These patients must be monitored closely for complications of the mild hyperthyroid state, such as bone mineral loss and development of atrial fibrillation. 

Heavy Metals. Some heavy metals such as gold and platinum are used pharmacologically as immunomodulators to treat rheumatoid arthritis and as antineoplastic drugs, respectively. Most heavy metals inhibit mitogenicity, antibody responses, and host resistance to bacterial or viral challenge, and tumor growth. Platinum has been shown to suppress humoral immunity, lymphocyte proliferation, and macrophage function (Lawrence, 1985). Clinically, mild to moderate myelosuppression may also be evident with transient leukopenia and thrombocytopenia. 

Zhang Z et al. (2006). Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth. Clin. Cancer Res. 12(16) 4933 1939. 

Dose (in vinca equivalents), administered on days 2, 5, 8, required to produce a 50% suppression of tumor growth relative to controls. The tumors were measured 28 days after tumor inoculation (s.c., I x 10 cells). T222 Animals pretreated with 350 R -/-radiation 24 hr prior to tumor inoculation and dosed on days 3, 6, and 9. 

Hurwitz, E., I. Stancovski, M. Sela, and Y. Yarden. Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Proc Nat Acad Sci USA. 92 3353-3357.1995. 

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