Angiogenesis, tumor-induced

Wartenberg M, Donmez F, Ling FC et al (2001) Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells. FASEB J 15 995-1005... 

Wartenberg M, Finkensieper A, Hescheler J et al (2006) Confrontation cultures of embryonic stem cells with multicellular tumor spheroids to study tumor-induced angiogenesis. Methods Mol Biol 331 313-328... 

However, a Pz can be expressed on tumor cells as well as on endothelial cells, making it difficult to attribute the resulting signal exclusively to molecular processes during tumor-induced angiogenesis. Thus, in cancer the most obvious use of this class of tracer could be for planning and controlling ay/fs-directed therapies. The value of noninvasive techniques for appropriate selection of patients who may benefit from such therapies is demonstrated by initial clinical... 

Another effect of LPS may be the inhibition of tumor angiogenesis. This was evidenced in melanoma B16- bearing C57BL/6 mice treated i.v. with the lipid A GL-60, after an IFN-y injection [114], It was confirmed in the same model using DT-5461 alone injected i.v. [94]. This effect of LPS is likely to be due to the production of TNF-a. This cytokine may be toxic for the endothelium [64], inhibiting at the same time the motility and proliferation of endothelial cells [59]. Sato et al. [115] showed that TNF-a inhibits tumor-induced angiogenesis in a rabbit corneal pocket assay. On the contrary, Vukanovic and Isaacs [116] concluded that TNF-... 

Aoki S, Cho S, Ono M, Kuwano T, Nakao S, Kuwano M, Nakagawa S, Gao J-Q, MayumiT, Shibuya M, Kobayashi M (2006) Bastadin 6, a Spongean Brominated Tyrosine Derivative, Inhibits Tumor Angiogenesis by Inducing Selective Apoptosis to Endothelial Cells. Anti-Cancer Drugs 17 269... 

Almost in vivo studies have been carried out on the ginsenosides (Fig. (1)). The /.v.(10-100 gg/mouse) or p.o. (100-1000 gg/mouse) multiple administration of ginsenoside-Rb2, 20 (R)- and 20 (S)-ginsenoside-Rg3 (Fig. (1)) isolated from red ginseng was demonstrated to inhibit lung metastasis produced by B16-BL-6 melanoma and colon 26-M3.1 carcinoma cells in syngeneic mice (Table 1) [18, 19]. The mechanism of their antimetastatic effect was related to the inhibition of the invasion and adhesion by tumor cells and also to the suppression of tumor-induced angiogenesis [18, 19]. 

Inhibition of tumor-induced angiogenesis through down- [112]... 

Wartenberg, M., Budde, P., De Marees, M., Grunheck, F., Tsang, S.Y., Huang, Y., Chen, Z.Y., Hescheler, J., and Sauer, H., Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional Chinese medicine. Lab. Invest., 83, 87-98,2003. 

MDA-MB-231 cells along with neutralized anti-VEGF antibody, this tumor-induced angiogenesis disappeared (Fig. 3G). Taken together, these results demonstrate that breast cancer cells can induce neovascularization around the tumor by secreting VEGF to the surrounding environment, and pl6 can inhibit this tumor cell-induced neovascularization. 

Tumor hypoxia results from a disparity between the demand and the supply of oxygen to the tumor tissue this consequence occurs when tumor cells are too distant from the vascular supply. By overcoming the hostile hypoxic environment, a tumor induces a new vascular supply to provide oxygen and nutrition - a process called angiogenesis. Accumulated evidences indicate that tumor hypoxia plays an important role in tumor progression and metastasis [5-8]. Studies both in vitro and in vivo demonstrated that hypoxic exposure of... 

Auerbach R, Arensman R, Kubai L, Folkman J. Tumor-induced angiogenesis Lack of inhibition by irradiation. Int J Cancer 1975 15 241-245. 

Griffioen AW, Damen CA, Mayo KH, Barendsz-Janson AF, Martinotti S, Blijham GFI, Groenewegen G. Angiogenesis inhibitors overcome tumor induced endothelial cell anergy. Int J Cancer 1999 80 315-319. 

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