Tuberculin-purified protein derivative

The most common carrier proteins in use today are keyhole limpet hemocyanin (KLH MW 4.5 X 105 to 1.3 X 107), BSA (MW 67,000), aminoethylated (or cationized) BSA (cBSA), thyroglobulin (MW 660,000), ovalbumin (OVA MW 43,000), and various toxoid proteins, including tetanus toxoid and diphtheria toxoid. Other proteins occasionally used include myoglobin, rabbit serum albumin, immunoglobulin molecules (particularly IgG) from bovine or mouse sera, tuberculin purified protein derivative, and synthetic polypeptides such as poly-L-lysine and poly-L-glutamic acid. 

PPD-kit (tuberculin-purified protein derivative, Cambridge Research Biochemicals Ltd, Macclesfield, UK). 

Mammalian tuberculin purified protein derivative (tuberculin PPD) is the active principle of old tuberculin. A small test dose in a healthy individual, given intracutaneously, is likely to produce only a little local pain and pruritus. If tuberculous infection is present, the local reaction is more marked, with vesiculation, ulceration, and even granuloma annulare or necrosis. 

Tuberculin purified protein derivative Aplisol injection 5 TU/0.1 mL, Tubersol injection 1 TU/0.1 mL, injection 5 TU/0.1 mL, injection 250 TU/0.1 mL, Tuberculin PPD multiple puncture device Apfitest injection 5 TU activity/test. Tine test PPD injection 5 TU activity/test) Tuberculin, a purified protein derivative, is an in vivo diagnostic biological agent that contains soluble products from Mycobacterium, which react with lyphocytes to release... 

Alternative test procedure for tuberculin. Purified Protein Derivative (PPD) Bovis, infradermic In vivo... 

Because of the risks of adverse reaction to the vaccine by persons who had already been exposed to the disease a sensitivity test must be carried out prior to immunization with BCG. A Mantoux skin test assesses an individual s sensitivity to a purified protein derivative (PPD) prepared fi om heat-treated antigens (tuberculin) extracted fiom M tuberculosis. A positive test imphes past infection or past, successful immunization Those with strongly positive tests may have active disease and should be referred to a chest clinic. Many people with active TB, especially disseminated TB, however, sero-convert fiom skin test positive to skin test negative. Results of the skin test must therefore be interpreted with care. 

Purified protein derivative (PPD) Material used in the tuberculin skin test, the most common test for exposure to Mycobacterium tuberculosis. 

A 35-year-old male has recently converted to positive on a purified protein derivative of tuberculin (PPD) test for TB. INH is given as prophylaxis. 

The most widely used screening method for tuberculous infection is the tuberculin skin test, which uses purified protein derivative (PPD). Populations most likely to benefit from skin testing are listed in Table 49-2. 

Synthetic peptide coupled to carrier such as KLH (Keyhole Limpet Hemocya-nin) or PPD (Purified Protein Derivative of tuberculin). 

Purified protein derivative The purified protein derivative test for tuberculosis may be recommended in patients with chronic or granulomatous uveitis. Sterile tuberculin protein injected intradermally on the forearm produces induration at the site of inoculation if the patient is seropositive for tuberculosis. Purified protein derivative should be ordered when the physical... 

Purified protein derivative (PPD of tuberculin) Derived from the tubercle bacillus and available from Statens Serum Institut, Copenhagen as a 1 mg/mL solution in PBS. Store at 4 C. 

In vivo diagnostics such as tuberculins, mallein, histoplasmin, coccidioidin and brucellin, are used to demonstrate an immune response, and hence previous exposure, to specific pathogens as an aid to diagnosis. Others, such as the Schick test (diphtheria) toxin are used to detect the presence of protective immunity. Because of their limitations, the trend has been to phase out these preparations, and tuberculins (as purified protein derivative, PPD) are now by far the most important of this group. 

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