Tryptophan hydroxylase gene

Yoshida, K. et al. (2002). Monoamine oxidase a gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry, 26, 1279-83. 

Serretti, A., Zanardi, R., Cusin, C. etal. (2001a). Tryptophan hydroxylase gene associated with paroxetine antidepressants activity. Eur. Neuropsychopharmacol., 11, 375-80. 

Furlong RA, Ho L, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC (1998) No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder. Am J Med Genet 81 245-247 Gaiter D, Unsicker K (2000a) Brain-derived neurotrophic factor and trkB are essential for cAMP-mediated induction of the serotonergic neuronal phenotype. J Neurosci Res 61 295-301... 

Maier DL, Mani S, Donovan SL, Soppet D, Tessarollo L, McCasland JS, Meiri KF (1999) Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice. Proc Nad Acad Sci U S A 96 9397-9402 Mansour-Robaey S, Mechawar N, Radja F, Beaulieu C, Descarries L (1998) Quantified distribution of serotonin transporter and receptors during the postnatal development of the rat barrel field cortex. Brain Res Dev Brain Res 107 159-163 Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF (1999) Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 45 603-614... 

Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M (1994) Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 51 34-38 Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M (1998) A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55 593-602... 

Serretti A, Zanardi R, Cusin C, Rossini D, Lorenzi C, Smeraldi E (200 lb) Tryptophan hydroxylase gene associated with paroxetine antidepressant activity. Em Nemopsychopharma-col 11 375-380... 

Ishiguro, H., Saito, T, Shibuya, H., Tom, M., and Arinami, T. (1999) The 5 region of the tryptophan hydroxylase gene mutation search and association study with alcoholism. / Neural Transm 106 1017-1025. 

Gelernter, J. (1997) Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am Psychiatry 154 1451-1453. 

G. L., Long, J.C., Goldman, D., and Linnoila, M. (1998) A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55 593-602. 

Tsai, S.J., Hong, C.J., and Wang, Y.C. (1999) Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors. Neuroreport 10 3773-3775. 

Han, L., Nielson, D.A., Rosenthal, N.E., Jefferson, K., Kaye, W., Murphy, D., Altemus, M., Humphries, J., Casssano, G., Rotondo, A., Virkkhunen, M., Linnoila, M., and Goldman, D. (1999) No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biol Psychiatry 45 615-619. 

Nolan KA, Volavka J, Lachman HM, Saito T. 2000. An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder. Psychiatr Genet 10 109-115. 

The first step of 5-HT biosynthesis is catalyzed by the rate-hmiting enzyme tryptophan hydroxylase (TPH). Two isoforms, TPHl and TPH2, have been identified in the periphery and in 5-HT neurons, respectively. Both isoforms are members of the aromatic amino acid hydroxylase gene family, together with phenylalanine (PAH) and tyrosine hydroxylases (TH). The human TPHl gene located on chromosome llplS.l, spans a region of 30 kb, contains at... 

Genes encoding for the biosynthesis and catabolism of neurotransmitters Tryptophan hydroxylase (TPH)... 

Serretti A, Zanardi R, Rossini D, Cusin C, LUli R, Smeraldi E (2001c) Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity. Mol Psychiatry 6 586-592... 

The aromatic amino add hydroxylases (AAHs) are a family of pterin-dependent enzymes comprising phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), and tryptophan hydroxylase (TPH, with two gene products TPH1 and TPH2). The AAHs perform the hydroxylation of aromatic amino adds and play an important role in mammalian metabolism and in the biosynthesis of... 

To better understand the roles of individual serotonin receptor subtypes in modulating the neural circuitry of complex behavior, a number of groups have generated "knockout" mice lacking individual serotonin receptor subtypes over the last decade. Overall, 10 (at least 14) serotonin receptor subtypes have been knocked out in mice, as well as several genes that regulate the development and activity of serotonin neurons (e.g., Pet-1, the serotonin transporter, and tryptophan hydroxylase). We review these studies, discuss their relevance to the pathophysiology of neuropsychiatric disorders, and close with a perspective on where the field may head in the future. 

Zill P, Baghai TC, Zwanzger P, et al. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry 2004 9( 11) 1030-1036. 

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