Tryptophan hydroxylase gene polymorphisms

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Tsai, S.J., Hong, C.J., and Wang, Y.C. (1999) Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors. Neuroreport 10 3773-3775. 

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Gelernter, J. (1997) Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am Psychiatry 154 1451-1453. 

Nolan KA, Volavka J, Lachman HM, Saito T. 2000. An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder. Psychiatr Genet 10 109-115. 

Zill P, Buttner A, Eisenmenger W, Moller HJ, Bondy B, Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry 2004 56(8) 581-586. 

We have mentioned in the second section of this review that tryptophan hydroxylase (TPH) is the rate limiting enzyme in the synthesis of 5-HT. The human TPH gene was localized to chromosome Ilpl4-pl5.3. The enzyme is tetrameric [88]. A polymorphism within intron 7 has been detected and that may influence 5-HT metabolism in the brain [89]. Hong et al [90] described an association between the TPH gene polymorphism (A218C) and schizophrenia. At present there are no association studies of autism and this polymorphism. However, the fact that the ontogeny of... 

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