Trimethyl-propanol

Tertiary butyl alcohol, trimethyl carbinol, tertiary butanol. 2-methyl-2-propanol, Me3COH. Colourless prisms, m.p. 25°C, b.p. 83°C. Prepared by absorbing isobutene (2-methylpropene) in sulphuric acid, neutralizing and steam distilling the liquor. Converted to isobutene by heating with oxalic acid. Potassium-/-buloxide is a very strong base. 

Trimethyl aluminum and propylene oxide form a mixture of 2-methyl-1-propanol and 2-butanol (105). Triethyl aluminum yields products of 2-methyl-1-butanol and 2-pentanol (106). The ratio of products is determined by the ratio of reactants. Hydrolysis of the products of methyl aluminum dichloride and propylene oxide results ia 2-methylpropeae and 2-butene, with elimination of methane (105). Numerous other nucleophilic (107) and electrophilic (108) reactions of propylene oxide have been described ia the Hterature. 

The water-insoluble salts such as Cs2,5Ho., iPWi204o efficiently catalyse dehydration of 2-propanol in the gas phase and alkylation of m-xylene and trimethyl benzene with cyclohexene this catalyst is much more active than Nafion-H, HY-zeolite, H-ZSM-5, and sulphated zirconia (Okuhara et al., 1992). 

The 3,4-dihydro-27/,6//,lltf//-[l,3]oxazino[2,3- ][l,3]benzoxazine 405 was Stained by treating 3-(2-hydroxyben-zamido)-l-propanol 404 with trimethyl orthoformate and formic acid (Equation 48) < 1999W099/33469>. 

Subtle ligand changes have pronounced effects in hydroboration of 1,1-disubstituted alkenes. Addition of HBcat across the C=C bond in 2,3,3-trimethyl-l-butene is catalyzed by [Rh(COD)Cl]2/DIOP at —5°C affording 2-t-butyl-l-propanol in 69% ee upon oxidation. In the case of 2-phenylpropene, [Rh(C2H4)2Cl]2 combines with either DIOP or BINAP to provide higher enantiomeric excesses than with [Rh(COD)Cl]2.46... 

Copper(l) chloride Copper chloride (8,9) (7758-89-6) tert-Butyl alcohol (8) 2-Propanol, 2-methyl- (9) (75-65-0) (3-Bromo-3,3-difluoropropyl)trimethylsilane Silane, (3-bromo-3,3-difluoropropyl)-trimethyl- (12) (134134-62-6)... 

Synonyms AI3-01288 Arconol BRN 0906698 r-BuOH f-Butanol tert-Butanol r-Butyl alcohol -Butyl hydroxide Caswell No. 124A CCRIS 4755 1,1-Dimethylethanol EINECS 200-899-7 2-Methyl-2-propanol 2-Methyl-/ propan-2-ol NCI-C55367 TBA Trimethyl carbinol Trimethylmethanol UN 1120. 

In mole fraction at 4.5 °C 0.605 in triethylenetetramine, 0.588 in triactyl trimethyl triethylene tetramine, 0.578 in hexamethylenediamine, 0.369 in A,A-dimethylacetamide, 0.297 in A-methyl-acetamide, 0.109 in adiponitrile, 0.114 in sebaconitrile, 0.188 in ethylene glycol, 0.390 in triethyl phosphate (Copley et al, 1941). Miscible in many alcohols including ethanol, propanol, butanol, and pentanol. 

Steele, W.V., Chirico, R.D., Knipmeyer, S.E., and Nguyen, A. Vapor pressure, heat capacity, and density along the saturation line measurements for benzenamine,butylbenzene, sec-butylbenzene, ferf-butylbenzene, 2,2-dimethylbutanoic acid, trideca-fluoroheptanoic acid, 2-butyl-2-ethyl-l, 3-propanediol, 2,2,4-trimethyl-l, 3-pentanediol, and l-chloro-2-propanol, J. Chem. Eng. Data, 47(4) 648-666, 2002a. 

Betanechol Betanechol, 2-carbamoyloxy-l-(A,A,iV-trimethyl)propyl ammonium chloride (13.1.8), is made by either the subsequent reaction of l-(iV,A,A-trimethylammonium) propan-2-ol with phosgene, followed by ammonia, or by a completely analogous synthesis of carbachol by the reaction of l-chloro-2-propanol with phosgene followed by consequent reactions with ammonia, and then with trimethylamine, giving betanechol (13.1.8) [14,15],... 

N-Benzyl-N-mesitylenesulfonyl)amino-1 -phenyl-1 -propanol Benzenesulfonamide, N-(2-hydroxy-1-methyl-2-phenylethyl)-2,4,6-trimethyl-N-(phenylmethyl)- (14) [R-(R, S )]-(187324-63-6), [S-(R, S )]-, (187324-64-7)... 

Fluorosilatrane (37) or its 3,7,10-trimethyl derivative (37a) are formed by the reaction of the corresponding 1-ethoxysilatranes (30, 30a) with concentrated HF in /-propanol at... 

Similarly, cyclohexene-3-one (162) gives in the first step l-trimethylsiloxy-3-TMS-l-cyclohexene (163) and by subsequent hydrolysis 3-TMS-cyclohexanone (264)108. If acetone is used instead, the system 242/Li/THF leads to 2-trimethyl-siloxy-2-TMS-propane (167) and after water treatment to 2-TMS-2-propanol (168)los ... 

A mixture of 59.5 g (0.2 mol) 2-(4-methoxybenzyl)-l,3,3-trimethyl-4-piperidone hydrochloride and 53.8 g (0.4 mol) of aluminum trichloride and 54.0 g of nitrobenzene in 1500 ml of dry benzene are boiled under reflux for 1 h. After cooling the reaction mixture is extracted with 750 ml 4 N sodium hydroxide solution, the temperature being maintained below 35°C. The organic phase is separated and extracted with 750 ml 1 N hydrochloric acid. The acid aequeous phase is rendered alkali by the addition of 100 ml 25% ammonia and extracted three times with 250 ml chloroform. The collected chloroformic phases are dried with sodium sulfate and evaporated under reduced pressure. The residue, 46.7 g, is converted into the hydrochloride by reaction with iso-propanol/HCI and crystallized from a mixture of methanol and ethylacetate. 44.6 g of the 5-hydroxy-2 -methoxy-2,9,9-trimethyl-6,7-benzomorphan hydrochloride are obtained, melting point 233-236° C (dec.). 

Fig. 6.5. Typical potentiometric (1,2,3,4) and conductometric (r,2, 3, 4 ) titration curves forCB SAE-30 Marinol engine oils. Plots fresh oil (4,4 ), used oils (1,1 2,2 3,3 ). Medium toluene (50%), 2-propanol (47.5%), water (2.5%), v/v mixture. The end-point = (2,4,6-trimethyl-pyridine + HC1). The empirical potential, E, obtained from samples for which a sharp inflection occurs (see curve 4), and is substituted for the potential to determine the end point (Fox et al.,...

To a solution of 4.0 g. (0.012 mole) of iridium tetrachloride (Note 1) in 4.5 ml. of concentrated hydrochloric acid is added ISO ml. of water followed by 50 ml. of trimethyl phosphite (Note 2). This solution is added to a solution of 30.8 g. (0.20 mole) of 4-t-butylcyclohexanone (Note 3) in 635 ml. of 2-propanol contained in a 2-1. flask equipped with a reflux condenser. The solution is heated at reflux for 48 hours (Note 4). At the end of this time the 2-propanol is removed on a rotary evaporator at reduced pressure, and the remaining solution is diluted with 250 ml. of water and extracted with four 150-ml. portions of el her. The ether solution is washed with two 100-ml. portions of wafer which are combined with the aqueous residue (Note 5). Tin ether extract is dried over magnesium sulfate or potassium carbonate and then concentrated on a rotary evaporator at reduced pressure to obtain cis-4-t-butylcyclohexano] as a w hite solid (2ft—31 g. 93-99%). Analysis of the crude product by glpc demonstrates it to contain 95.8-96.2 % eis-alcohol and 12 3 8 % of the trans isomer with essentially no ketone remaining (Note 6). Itecrystallization from 40% aqueous ethanol an nrds greater than 99% pure ri.s-alcohol, m.p. 82-83.5° after Hiihlimulion2 (Nole 7). 

C9H12N403 3,7-dihydro-8-methoxy-1,3,7-trimethyl-1 H-pur 569-34-6 25.00 1.3990 1 17308 C9H13NO 3-amino-3-phenyl-1 -propanol 14593-04-5 22.91 1.0318 2... 

Besides methanol, many other polar and nonpolar modifiers have also been used to successfully improve the separation in SFC. These modifiers include acetone, acetonitrile, acetic acid, butane, butanol, n-butyl chloride, carbon tetrachloride, dioxane, ethanol, formic acid, heptane, hexane, n-hexylamine, methylene chloride, nitromethane, propanol, proprionitrile, tetrahy-drofuran, toluene, triethanolamine, trifluoroacetic acid, trifluoroethanol, trimethyl phosphate, and water. 

In the key step, the glycosyl bromide (10) was treated with Zn in acetic acid in conditions typical of those of dissolving metal reduction, and this has led to the speculation that the elimination occurs by addition of two electrons from the metal to the C-1 carbonium ion formed by ionization of the halide, followed by elimination of the adjacent acetoxy group. Alternatively, organozinc intermediates could be involved. Protic solvents are necessary for the reaction and acetic acid can be replaced by ethanol or 1-propanol but if still milder conditions are required, the elimination can be effected with trimethyl phos-phite.20... 

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