2-Fluoroheptanoic acid

Fluoroheptanoic acid, 46,37 from 2-fluoroheptyl acetate by reaction with nitric acid, 46,37 toxicity of, 46,38... 

According to vapor phase chromatography in a 6-ft. column at 150° over silicone grease, the product contains about 8% of one impurity and 2% of another. It is sufficiently pure for conversion to 2-fluoroheptanoic acid.4... 

Fluoroheptanoic acid required no more than the usual precautions accorded organic compounds, for it and its precursors have LD50>100 mg /kg in mice The relatively low toxicity of this and other 2-fluoroalkanoic acids is in contrast to the high toxicity of the w-fluoro acids F(CH2)KCOOH with n an odd number (if n = 5, LD50 =1.3 mg./kg in mice).4... 

Esters and lactones can be oxidized at the alcoholic parts to give carboxylic acids with the same number of carbon atoms. 2-Fluoroheptyl acetate is transformed in 78-84% yield into 2-fluoroheptanoic acid by heating for 25 h at 48 °C with nitric acid and acetic acid [472]. 3,5-Dimethoxy-phthalide is converted into 3,5-dimethoxyphthalic acid in 90% yield by treatment with alkaline potassium permanganate at 0 °C for 12 h and at room temperature for 24 h (equation 468) [879]. 

B. 2-Fluoroheptanoic acid Note 2). A 250-ml. two-necked flask is fitted with a thermometer and a condenser that has an outlet tube to carry oxides of nitrogen to a gas absorption trap or the back of a hood. It is charged with 17.6 g. (0.100 mole) of... 

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