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Transmural necrosis

The groups consisted of 3-4 Sprague-Dawley female rats (160-180g). Each experiment was repeated at least twice and the results of those groups were pooled. The dopamine agonists MDO-NPA and NPA were injected sc once daily for seven days prior to the administration of cysteamine HC1 (Aldrich) 28 mg/100 g po three times with 3 h intervals. The dopamine antagonists NCA and (+)butaclamol were injected sc three times, 30 min before each dose of cysteamine. The animals were killed 48 h after the duodenal ulcerogen. The intensity of duodenal ulcer was evaluated on a scale of 0-3, where 0 = no ulcer, 1 = superficial mucosal erosion, 2 = transmural necrosis, deep ulcer, 3 = perforated or penetrated duodenal ulcer. [Pg.186]

Five cases of extensive mucosal necrosis and transmural infarction of the colon have been reported after the use of kayexalate and sorbitol enemas to treat hyperkalemia in uremic patients (30). The authors also studied the effects of kayexalate sorbitol enemas in normal and uremic rats and concluded that sorbitol was responsible for colonic damage and that the injury was potentiated in uremic rats. When sorbitol alone or kayexalate sorbitol were given, extensive transmural necrosis developed in 80% of normal rats and in all the uremic rats. [Pg.349]

The double perfusion of some parts of the heart explains that this area may be at least partially preserved in case of occlusion of one artery and that in case of necrosis the involvement is not complete (no transmural necrosis). [Pg.18]

Figure 9.2 Apical-anterior Ml. (A) ECG showing Q waves in V1-V3 with rS V4-V5 corresponding to an apical-anterior myocardial infarction. (B) CE-CMR image in a sagittal view myocardial hyperenhancement (arrows) shows a non-transmural necrosis of the anterior wall. (C-E) Transversal images show myocardial hyperenhancement (arrows) at low basal, mid and apical levels of the anterior... Figure 9.2 Apical-anterior Ml. (A) ECG showing Q waves in V1-V3 with rS V4-V5 corresponding to an apical-anterior myocardial infarction. (B) CE-CMR image in a sagittal view myocardial hyperenhancement (arrows) shows a non-transmural necrosis of the anterior wall. (C-E) Transversal images show myocardial hyperenhancement (arrows) at low basal, mid and apical levels of the anterior...
Five patients with uraemia developed severe eolonie necrosis after being given enemas containing sodium polystyrene sulfonate and sorbitol for the treatment of hyperkalaemia. Four of the 5 died as a result. Associated studies in uraemic rats found that all of them died over a 2-day period after being given enemas of sodium polystyrene sulfonate with sorbitol. Extensive haemorrhage and transmural necrosis developed. No deaths occurred when enemas without sorbitol were given. ... [Pg.1280]

Two patients, who had died after cardiac surgery, were in renal insufficiency, and had received sodium polystyrene sulfonate in sorbitol, had colonic luminal crystals of sodium polystyrene sulfonate associated with underlying mucosal necrosis, submucosal edema, and transmural inflammation (21). [Pg.2896]

Two women were investigated for cramping abdominal pain and bloody diarrhea (22). In only one did the episodes completely disappear after withdrawal of sumatriptan. The other underwent an exploratory laparotomy and right hemicolectomy for transmural bowel necrosis. [Pg.3527]

In case of ACS with ST-segment elevation (STE-ACS), the ECG patterns of ischaemia (subendocardial), injury (transmural) and usually necrosis appear in a sequential way (see Figures 3.7 and 8.5). In the case of exercise angina, the ECG pattern of subendocardial injury is the most frequently found (see Figures 3.9A and 4.57). [Pg.19]

If the delay is subepicardial or even transmural (see The concept of ECG patterns of ischaemia, injury and necrosis ) (p. 20). this delay of repolarisation without change of shape of TAP generates a flattened or negative T wave. [Pg.33]

The ischaemia that occurs clinically secondary to an acute total coronary artery occlusion is firstpredominantly subendocardial (symmetric and usually taller T wave) and then transmural and homogeneous (ST-segment elevation), and later, in general, a Q wave of necrosis appears,... [Pg.38]

On the contrary, in Q-wave infarction the coronary artery occlusion is usually complete, and classically it was considered that the MI was transmural and often presents homogeneous wall involvement (QS pattern) or at least the infarction involves the subendocardium and also part of the subepicardium in contact with the subendocardium (QR pattern) (Figure 5.2C). CMR has demonstrated that often Q-wave Mis are not trans-mural and, on the contrary, often are transmural non-Q-wave Mis (Moon et al., 2004). The Q-wave MI often appear in a patient without very much prior ischaemia (first infarction). Consequently, an acute ischaemia (ACS) generates a poor-quality TAP in the entire wall that is recorded, from the precordium, as subepicardial injury pattern (ST-segment elevation) (Figures 4.5 and 4.8). Later, the myocardium becomes non-excitable and Q wave of necrosis develops (Figures 5.2B and 5.3). [Pg.289]

Successful AF ablation depends upon achieving lesions that are reliably transmural (135,136). Radiofrequency energy consists of alternating electrical current which can be delivered to the myocardial tissue through a transvenous electrode catheter. The tissue resistivity results in dissipation of RF energy as heat, which conducts passively to deeper tissue layers. Most tissues exposed to temperatures of 50°C or higher for more than several seconds will show irreversible coagulation necrosis and... [Pg.109]

CI-947 (cynomolgus) Vasodilator/adenosine agonist Coronary arteries (arteries in other organs also affected) Medial smooth muscle cell necrosis, mixed transmural inflammation Albassam et al. (1998)... [Pg.400]

Inflammatory transmural angiitis in systemic lupus erythematosus, polyarteritis nodosa, or giant cell arteritis causes focal fibrinoid necrosis and elastic tissue disruption. Subacute or chronic changes usually produce ectasia and may facilitate aneurysm formation. Aneurysms in acute arteritis tend to be multiple, peripheral and non side-wall in configuration. [Pg.174]


See other pages where Transmural necrosis is mentioned: [Pg.2896]    [Pg.36]    [Pg.2051]    [Pg.470]    [Pg.214]    [Pg.333]    [Pg.2896]    [Pg.36]    [Pg.2051]    [Pg.470]    [Pg.214]    [Pg.333]    [Pg.85]    [Pg.495]    [Pg.43]    [Pg.852]    [Pg.1626]    [Pg.20]    [Pg.33]    [Pg.34]    [Pg.130]    [Pg.131]    [Pg.131]    [Pg.275]    [Pg.276]    [Pg.291]    [Pg.265]    [Pg.653]    [Pg.282]    [Pg.24]    [Pg.341]   
See also in sourсe #XX -- [ Pg.111 ]




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