Toxicology regulation

PDA, Everything Added to Eood in the United States, CRC Press, Boca Raton, 1993 Clydesdale, P.M., Eood Additives Toxicology, Regulation, and Properties, CRC Press, Boca Raton, 1997. 

Zbinden, G. (1993). The concept of multispecies testing in industrial toxicology. Regul. Toxicol. Pharmacol. 17 84-94. 

Kessova, I., and A.I. Cederbaum. 2003. CYP2E1 Biochemistry, toxicology, regulation and function in ethanol-induced liver injury. Curr. Mol. Med. 3(6) 509-518. 

Zbinden G. Predictive value of animal studies in toxicology. Regul Toxicol Pharmacol 1991 14 167-77. 

Kier LD. Use of the Ames test in toxicology. Regul Toxicol Pharmacol 1985 5 59-64. 

Clydesdale, F.M., Food Additives Toxicology, Regulation and Properties. Database on CD-ROM. CRC Press, Boca-Raton, FL, 1997. 

For food packaging applications, both additives and polymers need specific toxicological regulations from national health authorities. Because of severe requirements concerning safety, the demand for low-dust versions of additives is steadily increasing, to reduce to a minimum any contamination of human beings on handling. 

The OSHA limits, regulations, and recommendations apply to in-plant air quaUty. Improperly filtered exhaust air may cause a plant to be in violation of the EPA standard, therefore these data should not be confused with the EPA limit for airborne lead, 1.5 fig lead/m, measured over a calendar quarter, which pertains to the exterior plant environment and emissions. The installation and proper maintenance of exhaust filtration systems enables most plants to comply with the EPA limits for airborne lead (see Lead compounds, industrial toxicology). 

The toxicology, occupational health hazards, and transportation regulations of cesium compounds result from the anion rather than the cesium cation. Producers and distributors provide an MSDS as well as detailed shipping requirements for each product. 

Other toxicological effects that may be associated with exposure to benzyl chloride based on animal studies are skin sensitization and developmental embryo and/or fetal toxicity. A 1980 OSHA regulation has estabhshed a national occupational exposure limit for benzyl chloride of 5 mg/m (1 ppm). Concentrations of 160 mg/m (32 ppm) in air cause severe irritation of the eyes and respiratory tract (68). 

N. Dkiesen, FoodTechnol, 40 (May 1975). Toxicology and Regulation of Natural Colors. Some thoughts on international regulation. 

Toxicology often provides the basis for a number of regulations aimed at protecting workers from potentially harmful effects. Today, more than ever before, toxicology has a preventive function that provides information on chemicals that can be used safely. It is difficult to imagine occupational or other safety regulations without a major input from toxicology. 

On the basis of the available toxicological data and experience, alkane-sulfonates are to be classified and labeled as irritant in accordance with EEC Regulations on Hazardous Substances. 

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