Toxicology biochemical aspects

Biochemical Aspects. The chemical and physical dissimilarities of trace elements account for their wide scope of toxicologic manifestations. 

Feron, V. J., van Beek, L., Slunp, P. and Beems, R. B. (1977). Toxicological aspects of alkali treatment of food proteins. In "Biochemical Aspects of New Protein Food",... 

Kanapilly G. M. (1977) Alveolar microenvironment and its relationship to the retention and transport into the blood of aerosols deposited in the alveoli. Health Phys. 32, 89-100. Kawanishi S. (1995) Role of active oxygen species in metal-induced DNA damage. In Toxicology of Metals—Biochemical Aspects (eds. R. A. Goyer and M. G. Cherian). Handbook of Experimental Pharmacology, Springer, Berlin, vol. 115, pp. 349-372. 

An attempt has been made to give an overview of all chemical aspects of plant protection, with the exception of analytical chemistry. We are fully aware that the designation chemistry of pesticides does not cover an unequivocally defined, uniform branch of science, because the fundamental sciences on which it is built, particularly organic chemistry and biochemistry, have maintained their independence and their original scope also within the frame of this special field. The chemistry of pesticides integrates these fundamental sciences only functionally, and not with respect to their methods. Our book attempts to achieve this functional unity. In the discussion of individual compounds and types of compound our aim has been to cover preparative and organic chemical and biochemical aspects, metabolism, activity-structure relationships, fields of application, and environmental and toxicological problems. 

Goyer la and Cherian MG, eds. (1995) Toxicology of metals - Biochemical aspects. Springer-Verlag, Berlin-Heidelberg-New York-London-Paris-Tokyo-Hong Kong-Barcelona-Budapest. 

The biological data are subgrouped under three headings biochemical aspects, toxicological studies, and ob.servations in human.s. 

LACTAM ANTIBIOTICS - deals with the chemical and biochemical aspects of the -lactam antibiotics. Topics selected include the synthesis, biosynthesis, chemical reactivity, anti-microbial activity, pharmacodynamics, metabolism, toxicology, detection and analysis, and pharmaceutical applications of the penicillins, cephalosporins, and related compounds. 

RN Wixtrom, BD Hammock. In D Zakim, DA Vessey, eds. Biochemical Pharmacology and Toxicology Methodological Aspects of Drag Metabolizing Enzymes, Vol. 1. New York John... 

Hodgson, E. and Levi, P. (1994). A multiauthor text dealing in depth with some aspects of biochemical toxicology highly relevant to the present topic. Examples of metabolism and mode of action of insecticides, and PAHs. 

Manzo, L., C. Gregotti, A. Di Nucci, P. Richelmi. 1979. Toxicology of paraquat and related bipyridyls biochemical, clinical and therapeutic aspects. Vet. Human Toxicol. 21 404-410. 

The objective of the book has always been to form a sound introduction to the basic principles of the subject from a biochemical and mechanistic viewpoint. It is a testament to the vitality and progression of toxicology that the increasing sophistication, complexity, and expansion of the subject mean that revision of at least parts of this book is essential every few years. However, a book of this size cannot realistically cover all of the diverse aspects of toxicology in equal depth and detail and include all the new developments that are occurring, hence the extensive bibliography, which should be used to complement this text where more detail or other examples are wanted. 

Change can be expected in almost every aspect of both the applied and the fundamental aspects of toxicology. Risk communication, risk assessment, hazard and exposure assessment, in vivo toxicity, development of selective chemicals, in vitro toxicology, and biochemical and molecular toxicology will all change, as will the integration of all of these areas into new paradigms of risk assessment and of the ways in which chemicals affect human health and the environment. 

Sidorov, V.S.,Vysotskaya, R.U. and Nemova, N.N. (1993). Evolutionary aspects of ecologo-biochemical monitoring (In Russian). In Biochemical Methods in Ecology and Toxicological Researches (V. Sidorov, ed.), pp. 5-35, Karelian Scientific Centre Publishing, Petrozavodsk. 

Devine, M.D. and C.V. Eberlein (1997). Physiological, biochemical and molecular aspects of herbicide resistance based on altered target sites, pp. 295-348. In Roe, R.M. J.D. Burton, and R.J. Kuhr, eds., Herbicide Activity Toxicology, Biochemistry and Molecular Biology. Amsterdam, The Netherlands I. O. S. Press, Inc. 

A critical aspect of toxicological chemistry is that which deals with the biochemical mechanisms and reactions by which xenobiotic compounds and their metabolites interact with biomolecules to cause an adverse toxicological effect.6 7 The remainder of this chapter addresses the major aspects of biochemical mechanisms and processes of toxicity. 

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