Toxicology biochemical

Biochemical toxicology deals with processes that occur at the cellular and molecular levels when toxic chemicals interact with living organisms. Defining these interactions is fundamental to our understanding of toxic effects, both acute and chronic, and is essential for the development of new therapies, for the determination of toxic 

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A. de Bmin, Biochemical Toxicology of Environmental Agents, Elsevier Publishing Co., Amsterdam, 1976, p. 185. 

J. A. Timbrel/ Principles of Biochemical Toxicology, Taylor and Francis, Ltd., London, 1982, Chapt. 7. 

There are many texts dealing with the biochemical toxicology of organic compounds, but most of them are principally concerned with human toxicology. The following texts are suitable, in differing ways, as supplementary reading to the present chapter. 

Hodgson, E. and Levi, P. (1994). A multiauthor text dealing in depth with some aspects of biochemical toxicology highly relevant to the present topic. Examples of metabolism and mode of action of insecticides, and PAHs. 

Conjugate In biochemical toxicology, a structure (often an anion) formed by the combination of a xenobiotic (usually a phase I metabolite) with an endogenous component (e.g., glucuronate sulfate or glutathione). 

Timbrell, J.A. (1999). Principles of Biochemical Toxicology (3rd edition). London Taylor and Francis. 

Walker, C.H. (1994a). Comparative toxicology. In E. Hodgson and P. Levi (Eds.) Introduction to Biochemical Toxicology, Norwalk, CT Appleton and Lange, 193-218. 

Johnson MK. 1982. The target for initiation of delayed neurotoxicity by organophosphorus esters biochemical studies and toxicological applications. In Hodgson E, Bend JR, Philpot, RM, eds. Reviews of biochemical toxicology, Vol 4. New York Elsevier, 141-212. 

Bagchi D, Bagchi M, Hassoun E, et al. 1992c. Effect of endrin on the hepatic distribution of iron and calcium in female Sprague-Dawley rats. J Biochem Toxicology 7(l) 37-42. 

T. Satoh, Role of Carboxylesterases in Xenobiotic Metabolism , in Reviews in Biochemical Toxicology , Eds. E. Hodgson, J. R. Bend, R. M. Philpot, Elsevier, New York,... 

McNulty MJ Biochemical Toxicology of Inhaled Dimethylamine, pp 1-4. CUT Activities. Chemical Industry Institute of Toxicology August 1983... 

Smart, R.C. and Hodgson, E. (2008) Molecular and Biochemical Toxicology, John Wiley Sons, Inc., Hoboken, NJ. 

This requires a sound mechanistic base to be successful. It is this mechanistic base that comes within the scope of biochemical toxicology, which forms the basis for almost all the various branches of toxicology. 

Biochemical toxicology is concerned with the mechanisms underlying toxicity, particularly the events at the molecular level and the factors, which determine and affect toxicity. 

Hodgson E, Smart RC. Biochemical toxicology definition and scope. In Hodgson E, Smart RC, eds. Introduction to Biochemical Toxicology. 2nd ed. New York Wiley, 2001. 

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