Drag metabolism

Gene Regnlatoiy Mechanisms in Drag Metabolizing P450s... 

Kalow W (1992) Pharmacogenetics of Drag Metabolism. Pergamon Press, Oxford... 

Thus it was clear that drug metabolism can differ between ethnic groups, and data generated in one population cannot be directly extrapolated to another population. When such differences exist, one ethnic group may be at an increased risk of therapeutic failure or toxicity because of differences in drag metabolism. 

Drags - Metabolism - Textbooks. I. Trager, William, 1937- II. Title. 

Arif J, Khan S, Aslam M, et al. 1992. Diminution in kerosene-mediated induction of drag metabolizing enzymes hy asbestos in rat lungs. Pharmacology and Toxicology 71(l) 37-40. 

The biotransforming pathways are subject to manipulation and modification in a variety of ways. Drug metabolism also depends on age and sex. Drag metabolism may also produce toxic materials. 

Jayasagar G, Krishna Kumar M, Chandrasekhar K, Madhusudan Rao C, Madhusudan Rao Y. Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers. Drag Metabol Drag Interact 2002 19(l) 41-8. 

Conney AH. Induction of drag-metabolizing enzymes a path to the discovery of multiple cytochromes P450. Annu Rev Pharmacol Toxicol. 2003 43 1-30. 

Harris RZ, Jang GR, Tsunoda S. Dietary effects on drag metabolism and transport. Clin Pharmacokinet. 2003 42 1071-1088. 

Rae JM, Johnson MD, Lippman ME, Flockhart DA. Rifampin is a selective, pleiotropic inducer of drag metabolism genes in human hepatocytes studies with cDNA and oligonucleotide expression arrays. J Pharmacol Exp Ther 2001 299 849-857. 

Praeksaritanont T, Gorham LM, Hochman JH, et al. Comparative studies of drag-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells. Drag Metab Dispos 1996 24(6) 634 642. 

Mulder GJ, Jakoby WB. Sulfation. In Mulder GJ, ed. Conjugation Reactions in Drag Metabolism. New York Taylor and Francis, 1990 107-161. 

Drag metabolism involves the alteration of the chemical structure of the chug by an enzyme. It generally involves the transformation of a lipid-soluble drag (which can cross membranes and thus reach its site of action) into a more polar, water-soluble compound which can be rapidly eliminated in the urine. 

What is the principal mechanism of drag metabolism in the small intestine ... 

In summary, CACO-2 cells express many enzymes characteristic for intestinal cells involved in drag metabolism. The major drug metabolising enzyme, CYP 3A, is active only in selected clones pointing to polyclonal origin of CACO-2 and the necessity to characterize CACO-2 cells extensively for growth and experimental conditions used for given experiments. 

Further in vitro/in vivo investigations are needed to assess the relationship between CYP2C8 (and CYP2C9) polymorphisms and drag metabolic clearance, in order to address the clinical relevance of CYP2C8 genotyping. 

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