Toxicity RTECS data

For most of these compounds more toxicity information is included in the Registry of Toxic Effects of Chemical Substances (RTECS) data base.8 also for a large number of compounds in other tables. Further acid derivatives have been described.107 h Unless otherwise stated. ipr. Oral. 

Registry of Toxic Effects of Industrial Substances, 1985-86 ed. Sweet, D. V., Ed. National Institute of Occupational Safety and Health (NIOSH) Washington, 1988 see also RTECS data base. 

RTECS Registry of Toxic Effects of Chemical Substances 80,000 chemicals NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH Contains information about chemical substances, including threshold limit values, recommended standards in air, aquatic toxicity data, toxic effects data, regulatory information, review information, and references to specific toxicity data. The on-line version of NIOSH s Registry of Toxic Effects of Chemical Substances, revised quarterly... 

RTECS, compiled by NIOSH (U.S. National Institute for Occupational Safety and Health), is a comprehensive database of basic toxicity information and toxic-effects data on more than 100,000 chemicals. 

Inter-laboratory toxicity data has been used to develop a general, non-mechanistic model for predicting rat LD50 (8). Further, the correlatability of RTECS data in mechanistic terms was recently demonstrated by Lipnick in developing a bilinear logP relation for alcohol toxicity to rats (n 127) (9). One of our objectives is to uncover more complex mechanistic factors than the frequently reported dependance on logP. 

An example of a CIDS key search is given in Figure 7, where a search is shown for all cyclohexyl (SCN49) morpholine (SCN35) compounds in the NIOSH RTECS data base of acute toxicity. There are only two such compounds in the data base, and the first of these is printed out in the figure, along with its local NIOSH RTECS identifier numbers indicated. 

The only reported toxicity data on zinc fluoride in the NIOSH RTECS file is a LD q of 280 mg/kg for subcutaneous adniinistration in frogs. 

RTECS National Institute for Occupational Safety and Health (NIOSH) registry of toxic effects of chemical substances contains toxicity data and references commercially important substances... 

National Library of Medicine, NIOSH s Registy of Toxic Effects Chemical Substances (RTECS) database, Nov. 1994 rev. the data have not been critically evaluated. 

HSDB = Hazardous Substances Data Bank NCI = National Canoer Institute NIOSH = National Institute for Occupational Safety and Health OHM/TADS = Oil and Hazardous Materials/Teohnioal Assistance Data Systems RTECS = Registry of Toxic Effects of Chemical Substances... 

RTECS Registry of Toxic Effects of Chemical Substances number is a unique and unchanging number used to cross-reference the RTECS database, which is a compendium of data extracted from the open scientific literature. Six types of toxicity data are included in each file (1) primary irritation, (2) mutagenic effects, (3) reproductive effects, (4) tumorigenic effects, (5) acute toxicity, and (6) other multiple dose toxicity. 

RTECS number Registry of Toxic Effects of Chemical Substances number is published by NIOSH and present basic toxicity data on thousands of materials. 

A second disk in the series (CHEM Data) contains comprehensive information from the CHEMINFO, Registry of Toxic Effects of Chemical Substances (RTECS), and Chemical Evaluation Search and Retrieval System (CESARS) data bases, as well as recommendations on Transport of Dangerous Goods (TDG)/Hazardous Materials (49CFR). 

Toxicology Information on toxicity to aquatic life was obtained primarily from the peer-reviewed articles, Hartley and Kidd (1987), and the Chemical Hazard Response Information System (CHRIS, 1984). Information on toxicity to rats, mice, and other mammals was also obtained from the documented literature and from Hartley and Kidd (1987) and RTECS (1985). The absence of toxicity data does not imply that toxic effects do not exist. 

G. NIOSH RTECS Search System. The National Institute for Occupational Safety and Health (NIOSH), created in 1970, is required by law to prepare a list containing all the toxic effects of chemicals that can be found to have been recorded (24). The Registry of Toxic Effects of Chemical Substances (RTECS) is the data base created and updated annually by NIOSH to fulfill the provisions of this law. In 1977 the data base consisted of some 25,000 chemicals and the toxicity associated with these chemicals. 

---