RTECS database

National Library of Medicine, NIOSH s Registy of Toxic Effects Chemical Substances (RTECS) database, Nov. 1994 rev. the data have not been critically evaluated. 

RTECS Registry of Toxic Effects of Chemical Substances number is a unique and unchanging number used to cross-reference the RTECS database, which is a compendium of data extracted from the open scientific literature. Six types of toxicity data are included in each file (1) primary irritation, (2) mutagenic effects, (3) reproductive effects, (4) tumorigenic effects, (5) acute toxicity, and (6) other multiple dose toxicity. 

NIOSH, Detailed Description of the RTECS Database—Registry of Toxic Effects of Chemical Substances (http //www.nisc.eom/cis/RTECS Analysis March 2004.pdf). 

National Library of Medicine (1999 Registry of Toxic Effects of Chemical Substances (RTECS) Database, Bethesda, MD [Record No. 35205]... 

Approximately three decades ago, the U.S. government created the Registry of Toxic Effects of Chemicals (RTECS) database (www.ccohs.ca/education/asp/search rtecs.html). Initially available in book form only, it became later available on CD-ROM, from the National Institute of Occupational Safety and Health, USA, or affiliated vendors (e.g., the Canadian Center for Occupational Health and Safety [CCOHS] www.ccohs.ca). This database contains information on approximately 120,000 substances, including (where available) acute and chronic toxicity data for terrestrial organisms, primarily mammalian species, such as rats, mice, rabbits, monkeys, and humans. This database will be transferred to the private sector in the near future for maintenance. RTECS cannot be searched by structure, but by name, formula, CAS, and several other means. CCOHS provides also a website which allows limited searching of the RTECS database at ccin-foweb.ccohs.ca/rtecs/search.html, but access to data is for subscribers only. 

The prediction process relies on a pre-computed set of structural fragments that give rise to toxicity alerts in case they are encountered in the structure currently drawn. These fragment Usts and toxicities (e.g. mutagenicity) were drawn from the RTECS database. RTECS, the Registry of Toxic Effects of Chemical Substances, aims to Ust. .. aU known toxic substances. .. and the concentrations at which. .. toxicity is known to occur currently there are over 133,(X)0 such substance listed at http //www.ntis.gov/ products/types/databases/rtecs.asp loc=4-4-3. 

RTECS Database. Sodium Cyanide, National Institute for Occupational Safety and Health (NIOSH), Washington, DC (on RTECS CD-ROM, Canadian Centre for Occupational Health and Safety... 

The experiments used several subsets of the RTECS database as follows ... 

Similarity and Clustering of Chemical Structure Information Application to the RTECS Database to Explore Structure-activity Relationships for Chemical Toxicity Prediction Walsh, P.T. MSc Thesis, University of Sheffield, 1989. 

---