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Tolerances setting tolerance levels

Lincomycin (LIN) is an antibiotic used to treat human and animal diseases caused by grampositive bacteria. As a growth promoter, it is also added in subtherapeutic amounts to feed or drinking water for animals. The FDA set tolerance levels for lincomycin residues at 150 pg/kg for milk and 100 pg/kg for edible tissues of chicken and swine. Lincomycin is not yet approved... [Pg.678]

Economy of time and resources dictate using the smallest sized faciHty possible to assure that projected larger scale performance is within tolerable levels of risk and uncertainty. Minimum sizes of such laboratory and pilot units often are set by operabiHty factors not directly involving internal reactor features. These include feed and product transfer line diameters, inventory control in feed and product separation systems, and preheat and temperature maintenance requirements. Most of these extraneous factors favor large units. Large industrial plants can be operated with high service factors for years, whereas it is not unusual for pilot units to operate at sustained conditions for only days or even hours. [Pg.519]

Quality control is intended to monitor and evaluate the performances of both food and human processes that contribute to food quality. The basic principle of this function is the control circle that involves (1) the taking of a process sample by the analysis or measuring unit, (2) determining whether process results meet set tolerances or limits, (3) judging the character and level of any discrepancy, and (4) application of corrective action to adjust the system to an acceptable level (Figure 7.1.1). A distinction is made between measuring and analysis, whereby the first involves direct measurements (e.g., pH, temperature) and the second involves taking samples, sample preparation, and actual analysis. ... [Pg.555]

Adequate sensitivity is required to measure an analyte accurately at the MRL (or tolerance) set by the regulatory agency. Tolerances and MRLs sometimes differ between agencies and may change as new scientific evidence indicates that the residue level... [Pg.688]

The acceptable tolerance level of chlorpyrifos in meat and meat by-products destined for human consumption is 2.0 mg/kg fresh weight (Byford et al. 1986), and for agriculture products it usually ranges between 0.05 and 15.0 mg/kg FW and up to 25.0 mg/kg for citrus oil (USPHS 1995). The significance of these concentrations to animal health, or to consumers other than man, is unknown. More research is needed to establish maximum tolerable chlorpyrifos limits in tissues of sensitive fish and wildlife. Proposed air criteria for chlorpyrifos and human health include 200 pg/m3 in the workplace, and much lower concentrations of 0.48 to 3.3 pg/m3 in nonoccupational settings (USPHS 1995). No air criteria are currently available or proposed for protection of wildlife. [Pg.900]

Carbon Monoxide. Carbon monoxide, a fuel in high-temperature cells (MCFC and SOFC), is preferentially absorbed on noble metal catalysts that are used in low-temperature cells (PAFC and PEFC) in proportion to the hydrogen-to-CO partial pressure ratio. A particular level of carbon monoxide yields a stable performance loss. The coverage percentage is a function of temperature, and that is the sole difference between PEFC and PAFC. PEFC cell limits are < 50 ppm into the anode major U.S. PAFC manufacturers set tolerant limits as < 1.0% into the anode MCFC cell limits for CO and H20 shift to H2 and C02 in the cell as the H2 is consumed by the cell reaction due to a favorable temperature level and catalyst. [Pg.312]

Novobiocin (NBC) is used for the treatment of mastitis in dairy cattle. In 1982, the tolerance level was set at 100 pg/kg in milk from dairy animals. An HPLC assay was developed for NBC determination in bovine milk at a tolerance level (214). The milk sample was diluted with buffer, the proteins were precipitated with MeOH, and the solution was filtered. The filtrate was injected directly into an HPLC system with UV detection. The interlaboratory study was realized for the analysis of two concentrations of NBC in fortified control milk samples. Recoveries of NBC reported by the participating laboratories were 89-99% at 50 pg/kg, 93-101% at 100 pg/kg, and 89-100% at 2 mg/kg. The CVs ranged from 2.0% to 6.2%. All laboratories described the procedure as rapid and simple, allowing the preparation of 20 samples in less than 2 hours. [Pg.678]

Drug, and Cosmetic Act, Sections 408 and 409 for setting tolerances. A tolerance is the legal maximum residue concentration of a specific pesticide chemical allowed in or on a specific food or feed item. If residues exceed the tolerance, the food or feed is considered adulterated and is subject to seizure as it travels in interstate commerce. Tolerances are set at a level that represents the maximum residue likely to occur if the pesticide is used in accordance with the registered directions for use. [Pg.11]

The tolerance level establshed is set high enough to cover residues of all the significant components of the residue. [Pg.12]

Finally it should be noted that prior to the FQPA in 1996, the Delaney clause prohibited the establishment of tolerances or maximum allowable levels for food additives if it has been shown to induce cancer in human or animal. This is an important change in regulations because pesticide residues were considered as food additives. Because of the FQPA, pesticide residues are no longer regarded as food additives, and there is no prohibition against setting tolerances for carcinogens. [Pg.436]

The setting of MRLs for residues of veterinary drugs has been simplified somewhat since 1999, when the evaluation of old substances was completed and all MRLs are now developed and adopted by a unified central procedure. Much work has still to be done on the preparation and adoption of maximum levels for mycotoxins, heavy metals and other contaminants, such as PCBs and dioxins. Here one of the main factors delaying progress is the lack of data for toxicological evaluations and setting tolerable daily or weekly intakes. Furthermore, there is a lack of reliable data on levels of contaminants in individual foodstuffs and on dietary intakes of such substances. [Pg.290]

Step 6 allows us to create a statistical approach for the evaluation of the collected data. Using a statistical test and the statistical parameters selected in Step 6, we will be able to control decision error and make decisions with a certain level of confidence. Decision error, like total error, can only be minimized, but never entirely eliminated. However, we can control this error by setting a tolerable level of risk of an incorrect decision. Conducting Step 6 enables the planning team to specify acceptable probabilities of making an error (the tolerable limits on decision errors). At this step of the DQO process, the project team will address the following issues ... [Pg.23]


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