Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

MTD maximum tolerated

CC = cell count, CK = cytokines, i.v. = intravenously, s.c. = subcutaneously, MTD = maximum tolerated dose... [Pg.541]

Figure 1 Comparison of typical pharmacokinetic profiles seen for conventional versus controlled release formulations. Abbreviations. MEC, minimum effective concentration MTD, maximum tolerable dose. Figure 1 Comparison of typical pharmacokinetic profiles seen for conventional versus controlled release formulations. Abbreviations. MEC, minimum effective concentration MTD, maximum tolerable dose.
Abbreviations B[a]P, benzo[a]pyrene BCME, / /5-(chloromethyl)ether GLP, good laboratory practice IRIS, Integrated Risk Information System MTD, maximum tolerated dose. [Pg.96]

Figure 15-2 Schematic illustration of potential advantages of genomic biomarkers in a dosetime plot of toxicological study. Histopathology lesion is expected to occur when an animal is dosed between MTD (maximum tolerated dose) and NOEAL (no observed adverse effect level). The triangles and circles indicate where a biomarker can be detected or applied to indicate late injury. Genomic marker A is more predictive than clinical chemistry marker C because it can be detected earlier under the same dose treatment and is more sensitive as it works at a lower dose compared to another presumed clinical chemistry marker D. Figure 15-2 Schematic illustration of potential advantages of genomic biomarkers in a dosetime plot of toxicological study. Histopathology lesion is expected to occur when an animal is dosed between MTD (maximum tolerated dose) and NOEAL (no observed adverse effect level). The triangles and circles indicate where a biomarker can be detected or applied to indicate late injury. Genomic marker A is more predictive than clinical chemistry marker C because it can be detected earlier under the same dose treatment and is more sensitive as it works at a lower dose compared to another presumed clinical chemistry marker D.
DNA Deoxyribonucleic acid MTD Maximum tolerable dose, Maxi-... [Pg.2974]

MRC Medical Research Council, United Kingdom MSDS Material safety data sheet MTD Maximum tolerated dose MW Molecular weight NCE New chemical entity... [Pg.333]

The in-vivo growth inhibition in selected xenografts for the lead compounds compared to cisplatin and carboplatin are shown in Table II. In these experiments dose dependence of activity is established (not shown) and the best results are at the MTD (maximum tolerated dose). JM216 administered orally... [Pg.35]

MTD Maximum Tolerated Dose is the maximum dose that does not cause unacceptability morbidity or is not lethal to the test animals. [Pg.41]

See other pages where MTD maximum tolerated is mentioned: [Pg.1556]    [Pg.123]    [Pg.294]    [Pg.549]    [Pg.233]    [Pg.249]    [Pg.765]    [Pg.824]    [Pg.549]    [Pg.23]    [Pg.200]    [Pg.475]    [Pg.854]    [Pg.536]    [Pg.502]    [Pg.1638]    [Pg.88]    [Pg.48]    [Pg.219]    [Pg.96]    [Pg.293]    [Pg.13]    [Pg.4]    [Pg.107]    [Pg.231]    [Pg.83]   


SEARCH



Maximum tolerated dose (MTD

© 2024 chempedia.info