Tissue localization

Debes GF, Bonhagen K, Wolff T, et al. CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection. J Virol 2004 78 7528-7535. 

The endothelium has many diverse functions that enable it to participate in in-flammatoiy reactions (H27). These include modulation of vascular tone, and hence control of local blood flow changes in structure that allow leakage of fluids and plasma proteins into extravascular tissues local accumulation and subsequent extravasation into tissues of leukocytes and synthesis of surface molecules and soluble factors involved in leukocyte activation (B43). The endothelial cells themselves can modulate vascular tone by the release of vasoactive substances such as prostacyclin, nitric oxide (NO), ET. Endothelium-derived vasoactive substances... 

Subtype Other names Threshold (°C) Other activating stimuli Channel selectivity (Po/Pms) Chromasomal location Tissue localization... 

Na l.9 NaN, SNS2, PN5 39,000 (3-Subunit type Na l.l Na pi.2 Na pi.3 Na pi.4 Low Noninactivating 3p21-24 Chromasomal location 19ql3 1 lq23 1 lq24 1 lq23 Almost exclusively DRG (small cells only) Tissue localization CNS, muscle CNS CNS mainly DRG, CNS and muscle... 

Vaughn KC, Duke SO. Tissue localization ofpolyphenoloxidase mSorghum. Protoplasma 1981 108 319-327. 

HD is locally and systemically corrosive to human tissue. Local effects include immediate inflammation of the tissues around the eyes and pronounced reddening of the skin. If not decontaminated, the reddened skin will ulcerate into watery boils within 4 to 6 hours. If the blisters are crudely broken, they will often reblister. 

Nitric oxide (NO) has also been implicated in certain maternal behaviors, including the timing of parturition in rats and olfactory memory formation in lactating sheep (Gammie and Nelson, 1999), as well as aggression and maternal aggression. Nitric oxide is produced from L-arginine by three different tissue-localized nitric oxide synthase (NOS) enzymes neuronal (nNOS), en-... 

Hutzler, P. et al.. Tissue localization of phenolic compounds in plants by confocal laser scanning microscopy, J. Exp. Bot., 49, 953, 1998. 

PGH2 is the precursor of various prostaglandins and thromboxanes. Each reaction is catalyzed by a separate tissue-specific enzyme as indicated in figure 19.19. The tissue localization of the enzyme relates to the role of the... 

Fujiwara, S., Takeo, N., Otani, Y., Parry, D. A. D., Kunimatsu, M., Lu, R., Sasaki, M., Matsuo, N., Khaleduzzaman, M., and Yoshioka, H. (2001). Epiplakin, a novel member of the plakin family originally identified as a 450-kDa human epidermal autoantigen Structure and tissue localization. / Biol. Chem. 276, 13340-13347. 

Figure 7.5 Tissue localization of HMG-R expression. Exposed whole mounts show that HMG-R mRNA is observed in the midgut of JH Ill-treated male D. jeffreyi (A) and I. pini (C), but not in untreated insects (B, D). Panels E through H show whole mount hybridizations of isolated I. pini alimentary canals. HMG-R expression in the anterior midgut (AMG, marked by brackets) correlates with pheromone production in starved, JH Ill-treated males (E) and fed males (G), while starved and untreated males (F, G), which do not produce monoterpenoid pheromone components, do not strongly express HMG-R. Asterisks mark non-specific signal in the hindguts. PV, pro-ventriculus HG, hindgut. Scale bars = 0.5 mm. Figure modified from Hall et al. (2002a, 2002b) with permission.

OBPs have now been identified from numerous species of several insect Orders, including Lepidoptera, Diptera, Coleoptera and Hymenoptera (holometabolous insects), as well as Hemiptera and Phasmatodea (ametabolous insects). A recent classification defining OBP-Typel and OBP-Type 2 has been proposed by Vogt et al. (1999), based on phylogeny, tissue localization and structural features. 

Results from in vitro experiments, catalytic properties, and tissue localization are all compatible with the role of SCCE in the degradation of intercellular cohesive structures in the stratum corneum as part of the events leading to remodeling of the tissue and eventually to desquamation. Increased expression of SCCE in the epidermis of transgenic mice leads to impaired barrier function with increased transepidermal water loss. The transgenic animals have a thickened epidermis and a marked hyperkeratosis, possibly reflecting compensatory reactions.47-48 There are also other proteases... 

---