Tissue engineering applications poly

H. Adeli, S. H. S. Zein, S. H. Tan, H. M. Akil, A. L. Ahmad, Synthesis, characterization and biodegradation of novel poly(L-lactide)/multiwalled carbon nanotube porous scaffolds for tissue engineering applications., Current Nanoscience, vol. 7, pp. 323-333,2011. 

Li WJ et al (2006) Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. Acta Biomater 2(4) 377-385... 

Porter JR, Henson A, Popat KC (2009) Biodegradable poly(epsilon-caprolactone) nanowires for bone tissue engineering applications. Biomaterials 30(5) 780-788... 

As mentioned earlier, poly(NIPAAm-co-AAc) where AAc content is small (2-5 mol%) forms loose hydrogels above the LOST. This makes the system an attractive candidate for tissue engineering application as an extracellular matrix (ECM). Above a critical concentration, aqueous polymer solutions of W-isopropylacrylamide copolymers with small amounts of acrylic acid, synthesized in benzene by free radical polymerization, exhibited four distinct phases as the temperature increased a clear solution, an opaque solution, a gel, and a shrunken gel. The transition between the opaque solution phase and the gel phase was in the range of 30-34°C and was... 

Misra, S. K. et al. Poly(3-hydroxybu1yrate) multifunctional composite scaffolds for tissue engineering applications. Biomater. 2010,31(10), 2806-2815. 

Shalumon, K. T., Binulal, N. S., Selvamurugan, N., Nair, S. V., Deepthy, M., Furuike, T. (2009]. Electrospinning of carboxymethyl chitin/poly (vinyl alcohol] nanofibrous scaffolds for tissue engineering applications, Carboh rdn ol m., 77, 863-869. 

Polyanhydrides have been developed into various systems with mainly bone tissue engineering applications in mind. These polymers have mechanical strength much lower than that of bone but have been combined with other polymers, such as poly(imide)s, to resolve this problem. Polyanhydrides have been developed into photo-cross-linkable systems, based on dimethacrylated anhydrides, and also injectable systems, but little interest into these polymers with regard to tissue engineering has been taken in the recent past [82]. 

So far, polyanhydrides have only been approved by the FDA as a drug dehvery system commercially produced by Guilford. Chemotherapeutic agent BCNU (carmustine) loaded in poly(CPP-SA) 20 80 wafer (Gliadel ) was used for treating brain tumors [161,194,195], More applications in controlled release include eye disorder, local anesthetics, and anticoagulants [194], Further biocompatibility analyses need to be conducted for the use of polyanhydrides in other tissue engineering applications. 

Malheiro, V. N., Caridade, S. G., Alves, N. M., and Mano, J. F. 2010. New poly(e-caprolactone)/chitosan blend fibers for tissue engineering applications. Acta Biomaterialia 6 418-428. 

---