Copolymers of N-isopropylacrylamide

CA Cole, SM Schreiner, JH Priest, N Monji, AS Hoffman. Lower critical solution temperatures of aqueous copolymers of N-isopropylacrylamide and other N-substi-tuted acrylamides. ACS Symp Ser 350 255-284, 1987. 

Rzaev ZM, Dinner S, Pi kin E (2007) Functional copolymers of N-isopropylacrylamide for bioengineering applications. Prog Polym Sci 32 534-595... 

Schild, H. G. and D. A. Tirrell. 1991. Microheterogenous solutions of amphiphilic copolymers of N-isopropylacrylamide, An investigation via uorescence metltanhgmuir.7 1319-1324. 

Ivanov, A.E., Edink, E., Kumar, A., Galaev I.Y., Arendsen, A.F., Bruggink, A. and Mattiasson, B. (2003) Conjugation of penicillin acylase with the reactive copolymer of N-isopropylacrylamide a step toward a thermosensitive industrial biocatalyst. Biotechnol. Prog., 19, 1167. 

Another approach to achieve simultaneously steric stabilization and pH-sensitivity is, the combination of a PEG-lipid and a pH-sensitive copolymer such as terminally-alkylated copolymer of N-isopropylacrylamide and methacrylic acid (30, 31). 

Pridgen EM, Langer R, Farokhzad OC (2007) Biodegradable, polymeric nanoparticle delivery systems for cancer therapy. Nanomedicine 2 669-680 Rzaev ZMO, Dincer S, Piskin E (2007) Functional copolymers of N-isopropylacrylamide for bioengineering applications. Prog Polym Sci 32 534—595 Schild HG (1992) Poly (N-Isopropylacrylamide) - experiment, theory and application. Prog Polym Sci 17 163-249... 

MA2 Maeda, Y. and Yamabe, M., A unique phase behavior of random copolymer of N-isopropylacrylamide and W-diethylaciylamide in water. Polymer, 50, 519, 2009. 

Curcumin shows very interesting therapeutic properties in the fields of cancer, AIDS, or inflammation, but its use is limited by a low aqueous solubility and poor bioavailability. Nanocurc is a dispersion of curcumin, in micelles of synthetic block copolymer of N-isopropylacrylamide, N-vinylpyrrolidone, and poly(ethylene glycol)acrylate. Nanocurc is a water-soluble version of curcumin, with increased bioavailability and activity against tumor growth and metastases. The in vivo studies suggest that Nanocurc allows curcumin to cross the blood-brain barrier and exert an activity against inflammatory damages in the brain associated with Alzheimer s disease. ... 

The hydrogel membrane is a copolymer of N-isopropylacrylamide (NIPA) doped with methacrylic acid (MAA) and cross-linked with small amounts of ethylene glycol dimethacrylate (EGDMA). The prepolymer solution containing the monomers at the desired concentrations is poured between two glass plates separated by a 250 pm spacer. Polymerization is initiated using a combination of ammonium persulfate as free radical generator and tetraethylene-methylenediamine as accelerator. 

Meyer, O., D. Papahadjopoulos and J. C. Leroux, 1998, Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomes. FEBS Lett 421 61-64. 

Barker IC, Cowie JMG, Huckerby TN, Shaw DA, Soutar I, Swanson L (2003) Studies of the smart thermoresponsive behavior of copolymers of N-isopropylacrylamide and N, N-dimethylacrylamide in dilute aqueous solution. Macromolecules 36(20) 7765-7770. doi 10.1021/ma034250m... 

Hayashi H, Kono K, Takagishi T. Temperature sensitization of liposomes using copolymers of N-isopropylacrylamide. Bioconjugate Chem 1999 10 412-418. 

B. (2004) Thermoresponsive properties of sugar sensitive copolymer of N-isopropylacrylamide and... 

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