Ticlopidine interactions

Drug/Food interactions The oral bioavailability of ticlopidine is increased by 20%... 

Aluminum Hydroxide + Magnesium Carbonate (Gaviscon Extra Strength/ Liquid) [OTC] [Antacid/Aluminum Magnesium Salts] Uses Relief of heartburn, acid indigestion Action Neutralizes gastric acid Dose Adults. 15-30 mL PO pc hs Peds. 5-15 mL PO qid or PRN avoid in renal impair Caution T Mg (w/ renal insuff) [C, ] Disp Liq, chew tabs SE Constipation, D Interactions In addition to AlOH effects OF histamine blockers, hydantoins, nitrofurantoin, phenothiazines, ticlopidine, T effects OF... 

P2Y12 receptor is required for complete aggregation response to ADR Nevertheless, both (Fig. 6) receptors interact to lead the full response. ADP potentiates platelet secretion and irreversible aggregation, Enzymatic conversion of released ADP to inactive AMP by endothelial ecto-ADPase limits platelet activation by ADR Thienopyridines (ticlopidine, clopidogrel, prasugrel, cangrelor) are used for inhibiting ADP-induced platelet function in the prevention of acute coronary events,... 

Antibiotics, immune suppressive agents, antibodies for specific agonist receptors, synthetic peptide mimetics of interactive domains of cell matrix components, such as collagen, fibronectin fibrinogen, ticlopidine, disintegrins, proteins firom venoms, proteins from saliva of blood sucking animals and insects. 

Spaulding C, Charbonnier B, Cohen-Solal A, Juilliere Y, Kromer EP, Benhamda K, Cador R, Weber S. Acute hemodynamic interaction of aspirin and ticlopidine with enalapril results of a double-blind, randomized comparative trial. Circulation 1998 98(8) 757-65. 

Although there was no interaction between ciclosporin and ticlopidine in a pharmacokinetic study, a 64-year-old patient with a renal transplant had a reduction in the concentrationrdose ratio of ciclosporin after each of two successive courses of ticlopidine (298). 

Privitera M, Welty TE. Acute phenytoin toxicity followed by seizure breakthrough from a ticlopidine-phenytoin interaction. Arch Neurol 1996 53(ll) 1191-2. 

In two of the five spontaneous bleeding episodes described in Heading 4, medications that can affect platelet function or prothrombin time (PT) (i.e., aspirin and warfarin) were involved. Because GB is known to be an inhibitor of PAF (41), in theory GB could interact with antiplatelet drugs (e.g., aspirin, nonsteroidal anti-inflammatory drugs, clopidogrel, ticlopidine, dipyridamole) or anticoagulants (e.g., warfarin, heparin). EGb 761 was shown to potentiate the antiplatelet effect of ticlopidine in rats (42). However, in two studies in humans, the coadministration of GB with warfarin had no effect on either international normalized ratio or warfarin metabolism (43,44). 

Clinically important, potentially hazardous interactions with nitroglycerin, ticlopidine... 

Clinically important, potentially hazardous interactions with abciximab, anagrelide, anticoagulants, cilostazol, clopidogrel, dabigatran, dipyridamole, eptifibatide, salicylates, ticlopidine, tirofiban. Many herbals that possess anticoagulant or antiplatelet activity... 

Clinically important, potentially hazardous interactions with amprenavir, aprepitant, bedomethasone, buprenorphine, calcium, chloramphenicol, cimetidine, dobazam, clorazepate, cyclosporine, cyproterone, darunavir, dasatinib, delavirdine, dexamethasone, diazoxide, disulfiram, dopamine, fesoterodine, fluconazole, flunisolide, fluoxetine, fosamprenavir, ginkgo biloba, hydrocortisone, imatinib, indinavir, influenza vaccines, isoniazid, isradipine, itraconazole, lacosamide, lapatinib, lopinavir, meperidine, methylprednisolone, midazolam, mivacurium, nelfinavir, nilotinib, nilutamide, phenylbutazone, piracetam, posaconazole, prednisolone, prednisone, primrose, ritonavir, rivaroxaban, sage, saquinavir, solifenacin, St John s wort, sucralfate, telithromycin, temsirolimus, teniposide, ticlopidine, tizanidine, tolvaptan, triamcinolone, uracil/tegafur, vigabatrin... 

Makino, T., Wakushima, H., Okamoto, T., Okukubo, Y., Deguchi, Y., and Kano, Y. 2003. Pharmacokinetic and pharmacological interactions between ticlopidine hydrochloride and Kangen-Karyu—Chinese traditional herbal medicine. Phytother. Res. 17, 1021-1024. 

There are no documented drug interactions, but garlic s antiplatelet effect might be dangerous in patients taking warfarin or antiplatelet agents such as aspirin, clopidogrel, ticlopidine, or dipyridamole. 

Lopez-Ariztegui, N., M. Ochoa, M.J. Sanchez-Migallon, C. Nevado, and M. Martin (1998). Acute phenytoin poisoning secondary to an interaction with ticlopidine. Rev. Neurol. 26, 1017-1018. 

Colli, A. et al., Ticlopidine-theophyUine interaction, Clin. Pharmacol. Ther, 41(3) 358-362, 1987. 

Gidal, B.E. Sorkness, C.A. McGill, K.A. Larson, R. Levine, R.R. Evaluation of a potential enantioselective interaction between ticlopidine and warfarin in chronically anticoagulated patients. Ther. Drug Monit. 1995, 17, 33-38. 

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