Ticlopidine Phenytoin

Ticlopidine Phenytoin Risk of phenytoin toxicity Inhibition of phenytoin metabolism... [Pg.293]

Privitera M, Welty TE. Acute phenytoin toxicity followed by seizure breakthrough from a ticlopidine-phenytoin interaction. Arch Neurol 1996 53(ll) 1191-2. [Pg.3427]

Acetazolamide, allopurinol, aspirin, captopril, carbamazepine, chloramphenicol, chlorpromazine, dapsone, felbamate, gold salts, metronidazole, methimazole, penicillamine, pentoxifylline, phenothiazines, phenytoin, propylthiouracil, quinidine, sulfonamide antimicrobials, sulfonylureas, and ticlopidine... [Pg.119]

A careful study in six patients showed that ticlopidine 250 mg bd caused a two-fold increase in the Michaelis-Menten constant of phenytoin, indicating inhibition of... [Pg.2818]

Donahue S, Flockhart DA, Abernethy DR. Ticlopidine inhibits phenytoin clearance. Chn Pharmacol Ther 1999 66(6) 563-8. [Pg.2820]

Several reports have described ticlopidine-induced phenytoin toxicity with increased serum phenytoin concentrations (33-36). Data obtained in vitro using hepatic microsomal preparations have shown that ticlopidine inhibits the activity of CYP2C19 (37). [Pg.3426]

Rindone JP, Bryan G 2nd. Phenytoin toxicity associated with ticlopidine administration. Arch Intern Med 1996 156(10) 1113. [Pg.3427]

Klaassen SL. Ticlopidine-induced phenytoin toxicity. Ann Pharmacother 1998 32(12) 1295-8. [Pg.3427]

Donahue SR, Flockhart DA, Abernethy DR, Ko JW. Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Clin Pharmacol Ther 1997 62(5) 572-7. [Pg.3427]

Giancarlo GM, Venkatakrishnan K, Granda BW, von Moltke LL, Greenblatt DJ. Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro inhibition by sulfaphenazole, omeprazole, and ticlopidine. Eur J Clin Pharmacol 2001 57 31-6. [Pg.1612]

Carbamazepine, cholestyramine, dexamethasone, isoniazid, nafcillin, octreotide, phenobarbital, phenytoin, primidone, rifampin, sulfadimidine, sulfinpyrazone, ticlopidine Increase concentrations of CNIs... [Pg.870]

CYP2B6 <5 1-2 Bupropion Carbamazepi ne Cyclophosphamide Selegiline Flunitrazepam Meperidine Bupropion Selegiline Ethinylestradiol Phencyclidine Tamoxifen Ticlopidine Clotrimazole Carbamazepine Phenobarbital Phenytoin Pioglitazone Rifampin Troglitazone Valproic acid Ritonavir... [Pg.147]

CYP2C19 <5 5 Amitriptyline S-mephenytoin Omeprazole Phenytoin Phenobarbital Propranolol Diazepam Fluoxetine Fluvoxamine Ketoconazole Omeprazole Ticlopidine Topiramate Carbamazepine Rifampin... [Pg.147]

Lopez-Ariztegui, N., M. Ochoa, M.J. Sanchez-Migallon, C. Nevado, and M. Martin (1998). Acute phenytoin poisoning secondary to an interaction with ticlopidine. Rev. Neurol. 26, 1017-1018. [Pg.300]

Donahue, S., D.A. Flockhart, and D.R. Abemethy (1999). Ticlopidine inhibits phenytoin clearance. Clin. Pharmacol. Ther. 66, 563-568. [Pg.300]

A study in 6 patients taking phenytoin alone found that ticlopidine 250 mg twice daily approximately halved the steady-state phenytoin... [Pg.567]

The metabolism of phenytoin to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) by the cytochrome P450 isoenzyme CYP2C19, and to a lesser extent by CYP2C9, in the liver is inhibited by ticlopidine.Further metabolism of HPPH to dihydroxylated products is mediated mainly by CYP2C19 and this may also be inhibited by ticlopidine. ... [Pg.567]

The interaction is established and clinically important, but its incidence is unknown. It would now be prudent to monitor serum phenytoin levels very closely in any patient if ticlopidine is added to established treatment, being alert for the need to reduce the phenytoin dosage. If ticlopidine is discontinued, the phenytoin dose may need to be increased. [Pg.567]

Ticlopidine reduces the metabolism of phenytoin. A number of case reports describe patients who developed phenytoin toxicity when ticlopidine was added. [Pg.567]

A 65-year-old man taking phenytoin 200 mg daily and clobazam developed signs of phenytoin toxicity (vertigo, ataxia, somnolence) within a week of starting ticlopidine 250 mg daily. His serum phenytoin levels had risen from 18 mg/L to 34 mg/L. When the phenytoin dosage was reduced to 200 mg daily the toxic symptoms disappeared within a few days and his serum phenytoin levels fell to 18 mg/L. To test whether an interaction had occurred, the ticlopidine was stopped, whereupon the serum phenytoin levels fell, within about 3 weeks, to 8 mg/L, during which time the patient... [Pg.567]

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