Pharmacological interactions

Figure 1 A schematic conceptualization of the three-compartment model of CNS penetration demonstrating the importance of intercompartmental unbound compound concentration relationships to target pharmacology interactions [21,22,25-28]. An exaggerated synapse is shown in the brain compartment to emphasize the locale of transmembrane proteins (squares) versus intracellular (oval) targets, and the matrix compound concentrations dictating their respective ligand-target interactions.

Chong, S., Fung, H-L., Biochemical and pharmacological interactions between nitroglycerin and thiols. Effects of thiol structure on nitric oxide generation and tolerance reversal. Biochem. Pharmacol. 42 (1993), p. 1433-1439... 

Fung, H-L., Chong, S., Kowaluk, E., Hough, K., Kakemi, M., Mechanisms for the pharmacological interaction of organic nitrates with thiols. Existence of an extracellular pathway for the reversal of nitrate vascular tolerance by N-acetylcytseine. J. Pharmacol. Exp. Ther. 245 (1988), 524-530... 

The in vivo microdialysis procedure has corroborated many theories of memory function that were derived originally from studies examining the effects of drugs or lesions on behavioral measures of memory. In vivo microdialysis has provided neurochemical correlates of memory and has also proven to be a useful tool for studying pharmacological interactions within and between brain areas during memory-related processes. 

SOOl 2 Molina Cuevas, V., M.L. Arruzazabala, D. Carbajal Quintana, R. Mas Ferreiro, and S. Valdes Garcia. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998 29(1) 21-24. 

Antihepatotoxic actions of traditional Chinese medicines. 2. The pharmacological interaction of components of a dai-saiko to-employing complement-mediated cytotoxicity in primary cultured mouse hepatocytes. Phytother Res 1990 4(1) 36-38. 

Bourgeois, B.F. (1988) Pharmacologic interactions between valproate and other drugs. Am J Med 84 29-33. 

Katzenellenbogen JA, O Malley BW, Katzenellenbogen BS. Tripartite steroid hormone receptor pharmacology interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones. Mol Endocrinol. 10, 119-131, 1996. 

However, in the p-i concept there is a pharmacological interaction (low affinity) between the drug and the peptide-MHC molecule on the surface of the APC, with weak binding but sufficient to activate T cells, which have receptors for the MHC. 

JB Rand, CD Johnson. Genetic pharmacology interactions between drugs and gene products in Caenorhabditis elegans. Meth Cell Biol 48 187-204, 1995. 

A further consideration is which barbiturate to employ. We recommend the use of barbital because this substance, in contrast to many other barbiturates, undergoes no metabolism (Remmer 1972 Simon et al. 1992). For this reason, results obtained can be more readily interpreted in terms of a pharmacological interaction without confounding by pharmacokinetic or metabolic factors. 

Jones CK, Eberle EL, Shaw DB, McKinzie DL, Shannon HE. 2005. Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats. J Pharmacol Exp Ther 312 1055-1063. 

Joos AA. Pharmakologische Interaktionen von Antibiotika und psychopharmaka. [Pharmacologic interactions of antibiotics and Psychotropic drugs.] Psychiatr Prax 1998 25(2) 57-60. 

Calvo G, Garcia-Gea C, Luque A, Morte A, Dal-Re, Barbanoj M. Lack of pharmacologic interaction between paroxetine and alprazolam at steady state in health volunteers. J Clin Psychopharmacol 2004 24(3) 268-76. 

Pharmacological Interactions Between Antiretrovirals and Other Medications with Activity in the Central Nervous System... 

The pharmacological interactions of the antiepileptic drugs phenjdoin, carbamazepine, and phenobarbital with albendazole have been studied in 32 adults with active intraparenchjmatous neurocysticercosis (41) ... 

Krasinski K, Kusmiesz H, Nelson JD. Pharmacologic interactions among chloramphenicol, phenytoin and pheno-barbital. Pediatr Infect Dis 1982 l(4) 232-5. 

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