Thl cells

PAMPs and various tissue factors can prime DCs to produce T-cell-polarizing factors [21], IL-12 is a pro-inflammatory cytokine that induces IFN-y and promotes the development of Thl-cell differentiation [31], Other Thl-polarizing factors are IFN-a and IFN-(3 [32] and cell-surface expressed intracellular adhesion molecule (ICAM)-l [33]. On the other hand, it has been shown that NF-kB inducing kinase (NIK), which is known to regulate B-cell maturation and lymphoid organogenesis, is important for the induction of Thl7 cells [34],... 

T helper 1 (Thl) CXCR3, CCR5 Thl cells are a subset of CXCR3+ cells... 

Odum N, Bregenholt S, Eriksen KW, et al. The CC-chemokine receptor 5 (CCR5) is a marker of, but not essential for the development of human Thl cells. Tissue Antigens 1999 54 572-577. 

CXCR6 Synovium, PBMCs, SF CD4, CD8, CD4+ (CD45RA ) Present on activated memory Thl cells FACS 130, 173... 

Lynch EA, Heijens CA, Horst NF, Center DM, Cruikshank WW. Cutting edge IL-16/CD4 preferentially induces Thl cell migration requirement of CCR5. J Immunol 2003 171(10) 4965-4968. 

Thl cells producing IFN-y and IL-12 have been demonstrated to limit the development of fibrosis, whereas Th2 cells producing IL-4 and IL-13 have been... 

It is also more or less accepted that T-cells, in particular T-helper cells (CD4+), may develop into either Thl cells or Th2 cells. By doing so, T-helper cells orchestrate the ensuing immune response by the types of cytokines they produce. Thl cells, by producing IL-12 and y-IFN, stimulate macrophages and/or cytotoxic T-cells to kill and destroy infected or malignant cells, or to initiate a delayed type hypersensitivity (DTH) reaction Th2 cells, by producing IL-4, IL-5, IL-10, IL-13, trigger B-cells to initiate antibody production. 

Kim, K.H. et al., Acidic polysaccharide from Panax ginseng, ginsan, induces Thl cell and macrophage cytokines and generates LAK cells in synergy with rIL-2, Planta Med, 64, 110, 1998. 

Thl Soluble Antigen presented by MHC II Clonal expansion CD4Thl Thl cells activated, release cytokines, activate macrophages, inflammation Tuberculin Rx, contact dermatitis, berylliosis... 

Beside the well-established role of Th2 cells in allergy, it also became clear that not only Th2, but also Thl cells can contribute to allergic pathology, specifically in atopic dermatitis such as in acute lesional skin [10], where IFN-y is known to induce cell death in keratinocytes causing the spongiform pathology observed in atopic dermatitis [11]. 

Histamine has been shown to intervene in the Thl, Th2, Treg cell balance and consequently antibody formation. Differential patterns of HR expression on Thl and Th2 cells determine reciprocal T-cell responses following histamine stimulation (table 2 fig. 1) [73]. Thl cells show predominant, but not... 

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