Sodium thiamylal

Thiamylal sodium for injection is a mixture of sodium thiamylal with anhydrous sodium carbonate. It is a pale yellow hygroscopic powder. Soluble in water. 

Thiamine hydrochloride, 1014 Thiamine mononitrate, 1015 Thiamine pyrophosphate, 1015 Thiamylal, 1015 Thiamylal sodium, 1015 Thiaver, 585 Thiazamide, 995... 

SYNS 5-ALLYL-5-(l-METPiYLBUTYL)-2-THIOBARBITL RATE SODIUM 5-ALLYL-5-(l-METHYL-BUTYL)-2-THIO-BARBITURIC ACID SODIUM SALT BURITAL SODIUM SODIUM-5-ALLYL-5-(l-METHYL-BUTYL)-2-THIOBARBITURATE SODIUM THIAMYLAL SURITAL SURITAL SODIUM (derivative) SURITAL SODIUM SALT THIAMYLAL SODIUM THIOMYLAL SODIUM... 

A 36-year-old man had two generalized tonic-clonic convulsions after receiving intrathecal tetracaine 8 mg to supplement inadequate block estabhshed by intrathecal administration of tetracaine 10 mg (205). His seizures were controlled with intravenous thiamylal sodium. He regained consciousness, but complained of dizziness and blurred vision. He had a sensory block to T4—5. 

Thiamylal sodium is a short-acting intravenous barbiturate anesthetic. 

Gaynor J S, Bednarski R M, Muir W W lil 1993 Effect of hypercapnia on the arrhythmogenic dose of epinephrine in horses anesthetized with guaifenesin, thiamylal sodium and haiothane. American Journal of Veterinary Research 54 315-321... 

Thiamylal Sodium. Thiamylal. sodium S-allyl-S-(l-methylbutyl)-2-lhiobarbituraie (Surital Sodium), is a highly hydrophobic thiobarbiturate that has. structural features closely related to those of thiopental. It has biological properties similar to those of thiopental. Intravenous administration induces unconsciousness within. seconds, and consciousness is regained within 30 minutes. 

Thiopental Sodium (ii) Ketamine Hydrochloride (Hi) Methahexital Sodium (/v) Hydroxydione sodium succinate (v) Thiamylal Sodium. 

Figure 2 A beagle dog was anesthetized with thiamylal sodium (Surital) and intubated. The vagosympathetic trunks of this dog had previously been exteriorized and placed in skin tubes. This enabled the positioning of copper blocks, with templates of the skin tube milled out, to be placed on the skin tubes. These copper blocks were cooled to 0°C with thermoelectric elements with the excess heat conducted away by water flowing through the adjacent heat sink. A small jar containing 20 mL of 10-M ammonia solution was transiently placed in proximity to the endotracheal tube while the dog inhaled one breath. Following spontaneous inhalation of the ammonia vapor, there were no changes in ECG, arterial blood pressure, nor was there any tachypnea.

Dose. Initially 3 to 6 ml of a 2.5% solution of sodium thiamylal intravenously. 

Sodium thiamylal, 1015 Sodium valproate, 1059 Solanidine, 971 Solanine, 971 Solantyl, 897 Solarium, 971 Solarium tuberosum, 971 Solaskil,701 Sola-Stick, 967 Solatran, 695 Solatubine, 971 Solatunine, 971 Solazine, 1044 Solfadiazina, 982 Solfammide, 991 Solfapirimidina, 982 Solfoton, 883 Solgol, 793... 

Representative Chemicals Amobarbital Apr-obarbital Butabarbital sodium Cyclobarbital Heptabarbital Hexobarbital Methohexital sodium Pentobarbital Secobarbital sodium Talbutal Thiamylal Thiopental sodium... 

The cyanoacetic acid obtained from monochloroacetic acid and sodium cyanide, is treated with hydrochloric acid and ethanol to yield the diethyl ester of malonic acid. The ester, in absolute ethanol, is reacted with the stoichiometric proportion of metallic sodium so as to replace only one active hydrogen of the methylene (CH2) group. Thereupon, a slight excess of the calculated amount of allyl bromide is added. The second replaceable hydrogen is abstracted with 1-methyl butyl bormide and the resulting product is made to react with a theoretical amount of thiourea to yield thiamylal. The free acid thus obtained is conveniently transformed into the official sodium salt by neutralization with a stoichiometric proportion of sodium hydroxide (1 1). 

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