Thio barbituric acid

It is, however, more likely that the discrepancies observed in the periodate oxidation of malonaldehyde concern mainly the hydroxylation step. In the mechanism proposed (5) for this reaction, it is the enol form of malonaldehyde which is hydroxylated. However, titrations of a solution of malonaldehyde, prepared by hydrolysis of an aqueous solution (33) of carefully distilled 1, 3, 3-tri-ethoxypropene (46, 47), both with strong base and with iodine, indicate that only about 80% of the enol form is present in the equilibrium solution. On the other hand, the thio-barbituric acid test (58, 59) gave consistently higher values for the malonaldehyde content of the solution. The fact that only about 80% of the enol form is present in the equilibrium solution is all the more important as it can be shown (56) by titration with strong base that the enolization is slow, and moreover does not seem to go to completion. 

More sensitive, and most frequently used, is the periodic acid-thio-barbituric acid assay devised by Warren22 and modified by Amin-off.107 122 In a reaction sequence initiated by periodate oxidation, the... 

The most commonly used barbiturates are thiopentone [5-ethyl-5-(l-methylbutyl)-2-thiobarbituric acid], methohexitone [l-methyl-5-allyl-5-(l-methyl-2-pentynyl) barbituric acid], and thiamylal [5-allyl-5-(l-methylbutyl)-2-thio-barbituric acid]. Thiamylal is slightly more Table 4.3 Incidence of life-threatening hypersensitivity reactions to intravenous anaesthetic agents... 

Uchiyama, M. andMihara, M. 1978. Determination of malonaldehyde precursor in tissues by thio-barbituric acid test. Anal. Biochem. 86 271-278. 

Witte, V.C., Krause, G.F., and Bailey, M.E. 1970. A new extraction method for determining 2-thio-barbituric acid values of pork and beef during storage. J. FoodSci. 35 582-585. 

Dave and Shah have reported a Gould-Jacod type reaction for the microwave-assisted synthesis of thieno[3,2-e]pyrimido[ 1,2-c]pyrimidines via intermediate thieno[2,3-d ] pyrimidines (Scheme 3.46)73. A one-pot synthesis of pyrano [2,3-d]pyrimidines was also described by Kidwai and co-workers starting from thiobarbituric acids. The thio-barbituric acid intermediates were also prepared by microwave heating, using basic alumina as the solid support (Scheme 3.46)74. 

Increased lipid peroxidation (LP), as determined by the measurement of thio-barbituric acid reactive substances (TBARS), is significantly elevated in various CNS regions of aging rats compared with young rats (R2). 

SYNS 5-ALLYL-5-(l-METPiYLBUTYL)-2-THIOBARBITL RATE SODIUM 5-ALLYL-5-(l-METHYL-BUTYL)-2-THIO-BARBITURIC ACID SODIUM SALT BURITAL SODIUM SODIUM-5-ALLYL-5-(l-METHYL-BUTYL)-2-THIOBARBITURATE SODIUM THIAMYLAL SURITAL SURITAL SODIUM (derivative) SURITAL SODIUM SALT THIAMYLAL SODIUM THIOMYLAL SODIUM... 

ALLYL-5-(l-METHYLBUTYL)-2-THIOBARBITURATE SODIUM see SOX500 5-ALLYL-5-(l-METHYLBUTYL)-2-THIO-BARBITURIC ACID SODIUM SALT see SOX500... 

P.G. Nouros, C.A. Georgiou, M.G. Polissiou, Determination of olive oil 2-thio-barbituric acid reactive substances by parallel flow injection, Anal. Chim. Acta 417 (2000) 119. 

On the basis of characteristic color-reactions for (acylated) neuraminic acids (for example, Bial s orcinol reaction140,159 and the thio-barbituric acid method181), quantitative methods for the determination of gangliosides have been developed (for example, on thin-layer plates157,161,184,182). 

Two types of reaction yield formyl pyruvic acid these are some P-eliminations (see below) and the periodate oxidation of most sialic acids. In each case the formyl pyruvate produced can be made to react with thio-barbituric acid to give an intensely coloured product, so giving the means of following P-eliminations and estimating very small amounts (1-2 (jig) of sialic acid. 

Synonyms Dihydro-5-(l-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6-(IH,5H)pyrimidinedione 5-allyl-5-(1-methylbutyl)-2-thio-barbituric acid thioseconal Trade names Surital... 

Vitamin A inhibited doxorubicin-induced membrane lipid peroxidation in rat tissue in vivo (CiAC-cio et al. 1993). Brain and heart membrane preparations from rats receiving vitamin A, assayed in vitro in the presence of a Fe " ascorbate induction system, showed a delay in the beginning of the lipid peroxidation and generated lesser amounts of thio-barbituric acid reactive substances, with respect in membranes from control rats. 

In another study, frozen headed and gutted pink salmon were dipped in water to form a glaze with a proprietary blend of natural FRIs dispersed in the water. When 2-thio-barbituric acid (TEA) values reach 4-5 mg/kg sample, sensory approval of the product drops. Figure 5A shows the effectiveness of the FRI blend in retarding TEA increase during frozen storage. 

Lipid peroxidation products (e.g., malondialdehyde, pentane, ethane, and thio-barbituric acid-reactive substances) are research tools that can be used to estimate peroxidative damage. 

Shepherd proposed a colorimetric method for pyrimidines substituted in the 2-position based on the red colour formed with 2-thio-barbituric acid. Since no colour is produced when the pyrimidine is substituted in either the 4- or the 6-position this reaction may be used for the determination of sulphadiazine in the presence of other sulphonamides, including sulphamerazine and sulphadimidine. 

Sulphadiazine Transfer a 1-ml aliquot of solution A to a 10-ml graduated flask and at the same time transfer a 1 -ml aliquot of standard sulphadiazine solution, 25 per ml, to a second 10-ml graduated flask and pipette 1 ml of 0-1N hydrochloric acid into a third 10-ml graduated flask for the blank. Dilute the contents of each flask to volume with thio-barbituric acid solution and place the flasks in a water-bath, inserting the stoppers when the solutions have attained the temperature of the bath and allowing to stand for one hour thereafter. Remove the stoppers, allow to cool and add water to volume, if necessary, to compensate for any evaporation. 

---