Tests of finished product

The complete TV set is assembled and packed in a standard customer delivery box with expanded polystyrene foam. Random samples of the packages are then subjected to the following tests. 

The package is allowed to slide down the plane and collide into the rigid support at the bottom. All faces and corners are impacted from either 1.5 m or 3.0 m. 

The packed TV set is rolled end over end for a given number of times in a specified way. 

This simulates long-distance lorry journeys. 

The set is thermally cycled and exposed to high humidity levels at elevated temperatures for several weeks to simulate tropical conditions -only carried out on export models. 

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The most common duties performed by an industrial laboratory are testing of raw materials and testing of finished products. 

Even where it is possible to omit routine or even any sterility testing of finished product, the sterility requirement should be retained in the finished product specification. 

While there are common legislative requirements for the testing of finished products where, in normal work, tiie equipment is stressed, such as... 

Quantitative tests for catalase activity find their greatest usefulness in examination of finished product. For this purpose gasometric methods (36) or chemical methods based upon measurement of residual hydrogen peroxide (2) may be used. In the use of these quantitative methods it might be well to observe the precaution of removing the skins. 

Activities Carried out Manufacture of active substance Manufacture of finished product Manufacture of intermediate or bulk Q Packaging only Importing Laboratory testing Batch control and batch release Storage and distribution Investigational medicinal products Other ... 

The Committee for Proprietary Medicinal Products [8] applied the BCS, with certain requirements, to dispense with bioequivalency tests if the active pharmaceutical ingredient is class I and the in vitro dissolution of the finished dosage form is fast [9], An active substance is considered highly soluble if the amount contained in the HDS of an IR product is dissolved in 250 ml of each of three buffers within the range of pH 1-8 at 37°C (e.g., pH 1.0, 4.6, and 6.8). There should be linear and complete absorption, which indicates HP to reduce the possibility of an IR dosage form influencing the bioavailability [8], The similarity of the dissolution profiles of the test and reference products is demonstrated in each of three buffers within the range of pH 1-8 at 37°C (e.g., pH 1.0,4.6, and 6.8). If there is rapid dissolution of the product, where at least 85% of the active substance is dissolved within 15 min, no further comparison of the test and reference is required. Further requirements include that excipients be well established and have no interaction with the pharmacokinetics of the active substance and that the method of manufacture of finished product... 

Methods used to determine the performance characteristics of finished products fall into Category III. Dissolution tests (excluding measurement) and drug release tests are examples of these types of methods. Precision is the only parameter required for these methods according to the regulatory guidances, although all validation parameters may be determined based on the intent of the method. 

The Cosmetics Directive prohibits the testing of finished cosmetic products and cosmetic ingredients on animals since 11 March 2009 (testing ban) for all human health effects with the exception... 

Samples of drug product are sampled for sterility testing per manufacturing site SOP, Collection of Finished Product Samples, included as (provide reference attachment number). 

Sample of Finished Product being sent Return Tested Material to ... 

Except for work on complete products, a test piece must be formed before the test can be carried out. In many cases, the test piece can be directly moulded but, particularly when tests on finished products are concerned, the specimens need to be cut and/or buffed to some particular geometric shape (Figure 4.1). It is convenient to consider separately, first the mixing and moulding leading up to a vulcanised (or thermoplastic) test piece or test sheet, and secondly the preparation of test pieces from moulded sheets or products. The preparation of test pieces for tests on raw rubber and unvulcanised compounds will be considered integrally with those tests in Chapter 6. 

Two of the most common tests for finished product that have acceptance criteria are content uniformity and dissolution. The United States Pharmacopeia (USP 25) requirements for content uniformity for both tablets and capsules as well as for dissolution are summarized in Tables 1-3. 

Test the finished product for ferric iron, by dissolving a little in water, adding a drop of 6 AT H2SO4 and a few drops of KSCN. A red color indicates ferric iron. 

If they are unstable, the samples of each given step may be analyzed as soon as collected. Alternately, if their stability is sufficient, the different liquid samples may be stored in the refrigerator until the filling is complete and they may be tested at the same time. If the freezing induces no degradation, a third possibility is to freeze the liquid samples and to analyze them at the same time as the samples of finished product. 

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