Testosterone binding

R9. Rasner, W., and Deakins, S. M., Testosterone-binding globulins in human plasma studies on sex distribution and specificity. J. Clin. Invest. 47, 2109-2116 (1968). 

Polanski, J. and Bonchev, D. (1990). Theory of the Wiener Number of Graphs. II. Ttansfer Graphs and Some of Their Metric Properties. MATCH (Comm.Math.Comp.Chem.), 25, 3-39. Polanski, J. (1997). The Receptor-Like Neural Network for Modeling Corticosteroid and Testosterone Binding Globulins. J.Chem.lnf.Comput.ScL, 37,553-561. 

Backon J. Ginger in preventing nausea and vomiting of pregnancy a caveat due to its thromboxane synthetase activity and effect on testosterone binding [letter]. Eur J Obstet Gynecol Reprod Biol 1991 42 163-164. 

One important group of nutrients, rarely included in the Western diet, is the essential fatty acids. These compounds are precursors to prostaglandins, which inhibit testosterone binding in the prostate. They also act as anti-inflammatory agents and restrain protein synthesis and cell growth in the prostate. The omega-3 marine lipids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to inhibit the growth of prostatic tumors. Flax seed, a rich source of essential fatty acids, has been shown to inhibit cancer metastasis in studies done with mice. 

Polanski, J. (1997) The receptor-like neural network for modeling corticosteroid and testosterone binding globulins. J. Chem. Inf. Comput. Sci., 37, 553-561. 

Corvol, R, and C. W. Bardin. 1973. Species distribution of testosterone-binding globulin. Biology of Reproduction 8 277-282. 

The current version of this approach uses N x N matrices (N being the number of molecules included in the data set), in which the 3D similarity indices of each molecule as compared to every other molecule of the whole set are the non-diagonal elements of the similarity matrix [1064, 1065]. In an application to the affinities of 31 steroids to corticosteroid- and testosterone-binding globulins (same data as used in CoMFA studies, e.g. [36]), Carbo index similarity matrices were calculated for the shape and the electrostatic potentials of all molecules. Using the similarity... 

Photocontrolled affinity chromatography of asparaginase Isolation of testosterone-binding globulin from bovine serum by affinity chromatography... 

Testosterone binds to the androgen receptor in the cytoplasm of cells. This produces structural changes that enable this complex to enter the nucleus of the cell. There it binds to chromosomal DNA and promotes genes carrying out transcription and translation. 

The first application of CoMFA is an illustrative example. It correlates the binding affinities of 21 steroids (e.g., 1 and 2) to human corticosteroid (CBG) and testosterone binding globulins (TBG), Since steroids are relatively rigid systems (with the exception of the side chains in position 17), the alignment was performed by a rigid body RMS fit of carbon atoms 3, 5, 6, 13, 14, and 17. 

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