Clusters 3-6 Testicular Cancer

Case reports of testicular cancer in aircraft repair and leather tannery facilities suggested possible association with dimethylformamide. Further research has failed to confirm this relationship. A screening effort at a leather tannery, where a cancer cluster had been noted, identified no additional cases. Mortality and cancer incidence studies and nested case-control investigations of testicular cancer and several other anatomical sites at several facilities with exposure to dimethylformamide noted no convincing associations. 

It is most probable that the causative agent for prostate cancer in leather tannery workers is a mixture of unknown composition. Working in the leather tanning industry is more commonly associated with increased prevalence of testicular cancer clusters. 7375 This is discussed in Chapter 34. 

Three different testicular cancer clusters have been reported among leather tannery workersJ6-8 These workers are exposed to a wide range of lipophilic and hydrophilic chemicals that include... 

A testicular cancer cluster was also reported among military aircraft repair personnel The chemicals these workers were exposed to included... 

Marshall EG, Melius JM, London MA, et al. Investigation of a testicular cancer cluster using a case control approach. Int J Epidemiol 1980 19(2) 269—73. 

Cluster 1 Childhood Leukemia 468 Cluster 2 Prostate Cancer 468 Clusters 3-6 Testicular Cancer 469 Cluster 7 Brain Cancer Cluster—Electronic Workers 469 Cluster 8 Brain Cancer Cluster—Petrochemical Workers 470 Cluster 9 Brain Cancers in Offspring of Electronic Workers 470 Cluster 10 Kidney Cancer Cluster 471 Cluster 11 Colorectal Cancer Cluster 471 Cluster 12 Multiple Cancer Cluster 471 Cluster 13 Lung Cancer Cluster 472 Cluster 14 Childhood Leukemia 472 Cluster 15 Multiple Cancer Clusters 473 Cluster 16 Toxic Waste Disposal Site-Related Clusters 474... 

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