Vaginal suppository

I = injection T = tablet C = cream Tr = transdermal, continuous delivery, P = parenteral VC = vaginal cream VS = vaginal suppositories Ca = capsule. 

Miconazole (Monistat) 2% cream, 5 g intravaginally for 7 days 100-mg vaginal suppository daily for 7 days ... 

Clotrimazole 500 mg vaginal suppository once weekly Fluconazole 100 or 150 mg orally once weekly Terconazole 0.8% cream 5 g vaginally once weekly Monthly... 

Miconazole nitrate vaginal suppositories contain not less than 90% and not more than 110%i of the labeled amount of C18H14CI4N2O HNO3. 

Xue et al. [30] prepared a vaginal suppository formulation containing miconazole nitrate and determined its content by P-matrix ultraviolet spectrophotometry. The production of the suppository was finished with melting by the excipient of glyceryl esters fatty acid of artificial synthesis. Quantitative assay was conducted with a P-matrix ultraviolet spectrophotometer. The suppository was smooth and met the clinical requirement of vaginal disease treatment. The method of assay was accurate. 

Baker, E. R., Best, R. G., Manfredi, R. L., Demers, L. M., and Wolf, G. C. 1995. Efficacy of progesterone vaginal suppositories in alleviation of nervous symptoms in patients with premenstrual syndrome. Journal of Assisted Reproduction and Genetics 12 205-209. 

The provision of the insertion of a drug into one of the body s orifices (such as rectal or vaginal suppositories)... 

Pessary. An instrument placed in the vagina to support the uterus or rectum or as a contraceptive device a medicated vaginal suppository. 

Vaginal cream contains mineral oil and vaginal suppositories contain an oleaginous base which may weaken rubber or latex products such as condoms, avoid use within 72 hr following treatment with vaginal cream or suppositories... 

For abortifacient purposes, the recommended dosage is a 20-mg dinoprostone vaginal suppository repeated at 3- to 5-hour intervals depending on the response of the uterus. The mean time to abortion is 17 hours, but in more than 25% of cases the abortion is incomplete and requires additional intervention. 

Topical 1% cream, solution, lotion 100, 200 mg vaginal suppositories Econazole (generic, Spectazole)... 

Topical 0.4%, 0.8% vaginal cream 80 mg vaginal suppositories Tioconazole (Vagistat-1, Monistat 1)... 

Suppositories are pharmaceutical dosage forms intended for administration of medicine via the rectum, vagina, or urethra that melt, soften, or dissolve in the body cavity. Rectal and vaginal suppositories are most common but urethral suppositories are sometimes used. Suppositories are indicated for administering drugs to infants and small children, severely debilitated patients, those who cannot take medications orally, and those for whom the parenteral route might be unsuitable. Suppositories are used to administer drugs for either systemic or local application. Local applications include the... 

A vaginal suppository based on bromocriptine was employed for the therapy of hyperprolactinemia [32]. The rationale of the local vaginal delivery of bromocriptine lies in the noteworthy side effects consequent to oral therapy gastrointestinal disorders, extensive hepatic degradation, and hypotension. The pessary based on bromocriptine proved to be effective in lowering serum prolactin to normal levels after 20 days of local therapy the treatment was well tolerated by the majority of the patients and a minimal vaginal irritation was observed. 

A vaginal suppository based on ornidazole, a drug characterized by the activity against bacteria and protozoa, demonstrated the same safety and effectiveness in the treatment of vaginitis as that of a tablet formulation in addition, the slippery and smooth surface of the suppository-facilitated application and the irritation in the vulva-vaginal region was reduced in comparison with that induced by the tablet formulation [33]. 

Butoconazole Femstat 3 Vaginal cream vaginal suppositories Vulvovaginal candidiasis... 

Miconazole (2%, 4% vaginal cream 100 mg, 200 mg vaginal suppositories) see comments for dosage Monistat-7, Monistat-3 Insert one applicatorful intravaginally at bedtime for 7 consecutive days (2%) or 3 consecutive days (4%). Alternatively insert one... 

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