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Glyceryl trinitrate tablets

Materials Required Glyceryl trinitrate tablets 20 glacial acetic acid (90% v/v) 5 ml phenoldisulphonic acid solution (heat 3 g of phenol with 20 ml of sulphuric acid on a water-bath for 6 hours, and transfer the resulting liquid to a stoppered vessel) 2 ml strong ammonia solution 20 ml potassium nitrate (previously dried at 105 °C) 1 g ... [Pg.310]

Part—IV has been entirely devoted to various Optical Methods that find their legitimate recognition in the arsenal of pharmaceutical analytical techniques and have been spread over nine chapters. Refractometry (Chapter 18) deals with refractive index, refractivity, critical micelle concentration (CMC) of various important substances. Polarimetry (Chapter 19) describes optical rotation and specific optical rotation of important pharmaceutical substances. Nephelometry and turbidimetry (Chapter 20) have been treated with sufficient detail with typical examples of chloroetracyclin, sulphate and phosphate ions. Ultraviolet and absorption spectrophotometry (Chapter 21) have been discussed with adequate depth and with regard to various vital theoretical considerations, single-beam and double-beam spectrophotometers besides typical examples amoxycillin trihydrate, folic acid, glyceryl trinitrate tablets and stilbosterol. Infrared spectrophotometry (IR) (Chapter 22) essentially deals with a brief introduction of group-frequency... [Pg.540]

Q66 When d ispensing sublingual glyceryl trinitrate tablets to a patient, they should be advised to ... [Pg.275]

The tablet was introduced by Thomas Brockedon in 1843, and glyceryl trinitrate tablets appeared in the British Pharmacopoeia of 1885. Since that time, many variations have appeared but the basic process remains unchanged. There are three main methods of tablet manufacture, with choice depending on the dose and the drug s physical properties such as compressibility and flow (Figure 2.2). A drug with a large... [Pg.97]

A monograph for Glyceryl Trinitrate Tablets was included in the British Pharmacopoeia of 1885, but no other tablet monograph appeared there until 1945. This was not due to lack of popularity of the dosage form itself, but rather the absence of suitable methods of quality control that were applicable to tablets. [Pg.3653]

Allow the person to use any coronary vasodilator medication he or she is carrying. (If the individual has no medication but confirms that he or she has angina, you may give a glyceryl trinitrate tablet or similar medication.)... [Pg.9]

The tablet was introduced by Thomas Brockedon in 1843, and glyceryl trinitrate tablets appeared in the British Pharmacopoeia of 1885. Since that... [Pg.109]

Drugs with antimuscarinic effects, such as the tricyclic antidepressants and disopyramide, depress salivation and many patients complain of having a dry mouth. In theory sublingual glyceryl trinitrate tablets will dissolve less readily under the tongue in these patients, thereby reducing their absorption and... [Pg.885]

Results are somewhat low, partly due to deterioration of the glyceryl trinitrate tablets with age, but also probably due to loss by reason of the complexity of the hydrolysis reaction as pointed out by Richmond. Experiments both with solution and tablets of glyceryl trinitrate have given low results by this method it is tedious, the blank determination very high and frothing occurs in the alkaline distillation. [Pg.283]

Annie s doctor diagnoses angina and prescribes glyceryl trinitrate (GTN) tablets, which are to be dissolved under the tongue, not swallowed. [Pg.38]

Dose. Usually the equivalent of 0.5 to 1 mg of glyceryl trinitrate sublingually, repeated as required doses of 5.2 to 38.4 mg daily are given by mouth as sustained-release tablets. [Pg.643]

Advantages are that quick effect is obtained, e.g. with glyceryl trinitrate as an aerosol spray, or as sublingual tablets which can be chewed, giving greater surface area for solution. Spitting out the tablet will terminate the effect. [Pg.107]

Nitrates can be administered by various routes. For example, glyceryl trinitrate is used not only as traditional sublingual tablets but also in the form of modified-release tablets, buccal tablets, aerosolized oral spray, intravenous injection, and topical ointment or skin patches for percutaneous absorption (23). These different formulations have been developed largely as a means of controlling the onset and duration of action of glyceryl trinitrate, since in conventional oral form its action is limited by marked hepatic first-pass metabolism. [Pg.2530]

Hypotension is a frequent adverse effect of nitrates (24), resulting from dilatation of arteries and veins. It can be associated with reflex tachycardia and palpitation, and even syncope on assuming an upright posture. Hypotension occurs particularly in old people, especially those with recurrent falls (SEDA-16, 196), and more commonly with glyceryl trinitrate oral spray than with sublingual tablets, because of its faster onset of action (24). It tends to occur more commonly in those who take nitrates infrequently. [Pg.2530]

Glyceryl trinitrate in sublingual tablets causes a burning sensation under the tongue, an indication of the activity of the formulation. Altered and later absent taste sensation developed in a patient taking long-term transdermal glyceryl trinitrate patches (15). [Pg.2531]

Glyceryl trinitrate, a volatile dmg with a chloroform/water partition coefficient of 109, diffuses from simple tablet bases into the walls of plastic bottles and into plastic liners used in packaging tablets. This partitioning can be prevented if there is included in the tablet formulation an agent (such as polyoxyethylene glycol) which complexes with the dmg substance, thereby increasing its affinity for the tablet phase - in other words, reducing its... [Pg.172]

Glyceryl trinitrate (GTN) is extremely effective at relieving the pain of angina but it has only a short half-life. Due to extensive first pass metabolism the drug is ineffective when taken orally and is administered sublingually or buccally in either tablet or aerosol form. [Pg.64]

A.J. Pryce, H.F. Heatlie and S.R. Chapman, Buccaling under the pressure influence of secondary care establishments on the prescribing of glyceryl trinitrate buccal tablets in primary care, BMJ 313 (1996), 1621-1624. [Pg.124]

Tablets of Glyceryl Trinitrate, B,P. For small quantities of glyceryl trinitrate such as are found in tablets colorimetric methods must be employed, unless sufficient tablets are available for the material to be extracted with ether or ethanol for the macro- or a semi-micro-method. A method is given in the IJ.S.P. where tablets equivalent to about 5 mg of glyceryl trinitrate are reduced with Devarda s alloy after ether extraction and saponification. Smith adapted Anderson s method (above) to small quantities of material by using Nessler s reagent to determine the ammonia produced after reduction by reduced iron and acid with this modification only five tablets are needed for the assay. The details are ... Tablets of Glyceryl Trinitrate, B,P. For small quantities of glyceryl trinitrate such as are found in tablets colorimetric methods must be employed, unless sufficient tablets are available for the material to be extracted with ether or ethanol for the macro- or a semi-micro-method. A method is given in the IJ.S.P. where tablets equivalent to about 5 mg of glyceryl trinitrate are reduced with Devarda s alloy after ether extraction and saponification. Smith adapted Anderson s method (above) to small quantities of material by using Nessler s reagent to determine the ammonia produced after reduction by reduced iron and acid with this modification only five tablets are needed for the assay. The details are ...

See other pages where Glyceryl trinitrate tablets is mentioned: [Pg.309]    [Pg.313]    [Pg.298]    [Pg.991]    [Pg.2530]    [Pg.449]    [Pg.309]    [Pg.313]    [Pg.298]    [Pg.991]    [Pg.2530]    [Pg.449]    [Pg.310]    [Pg.25]    [Pg.204]    [Pg.250]    [Pg.463]    [Pg.464]    [Pg.3949]    [Pg.1128]    [Pg.306]    [Pg.347]    [Pg.626]    [Pg.64]    [Pg.1075]    [Pg.283]   
See also in sourсe #XX -- [ Pg.310 ]

See also in sourсe #XX -- [ Pg.1076 ]




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