Tablets algin

Antacid/alginic acid (Gaviscon) 2 tablets or 1 5 mL after meals and at bedtime AND/OR C. Patient-directed therapy Over-the-counter H2RAs (each taken up to twice daily) - Cimetidine 200 mg - Lamotidine 1 0 mg - Nizatidine 75 mg - Ranitidine 75 mg OR Over-the-counter PPI (taken once daily) - Omeprazole 20 mg agent. 

Alginic Acid + Aluminium Hydroxide + Magnesium Silicate Tablets (500 mg + 100 mg + 25 mg)... 

T. Sirkia, H. Salonen, P. Veski, et al. Biopharmaceutical evaluation of new prolonged-release press-coated ibuprofen tablets containing sodium alginate to adjust drug release. Int. J. Pharm. 107 179-187, 1994. 

Yong et ah [175] developed an effective omeprazole buccal adhesive tablet with excellent bioadhesive force and good drug stability in human saliva. The omeprazole buccal adhesive tablets were prepared with various bioadhesive polymers, alkali materials, and croscarmellose sodium. Their physicochemical properties, such as bioadhesive force and drug stability in human saliva, were investigated. The release and bioavailability of omeprazole delivered by the buccal adhesive tablets were studied. As bioadhesive additives for omeprazole tablet, a mixture of sodium alginate and hydroxypropylmethyl cellulose was selected. The omeprazole tablets prepared with bioadhesive polymers alone had bioadhesive forces suitable for a buccal adhesive tablet, but the stability of omeprazole in human saliva was not satisfactory. Magnesium oxide is an alkali stabilizer for omeprazole buccal adhesive tablets. Croscarmellose sodium enhanced the release of omeprazole from the tablets but it decreased the bioadhesive forces and stability of omeprazole tablets in human saliva. 

Tarka Trandolapril/ verapamil HC1 1 mg/240 mg 2mg/180mg 2 mg/240 mg 4 mg/240 mg Extended release tablet Hypertension ACE inhibitor Com starch, dioctyl sodium sulfosuccinate, ethanol, HPC, HPMC, lactose, magnesium stearate, MCC, polyethylene glycol, povidone, purified water, silicon dioxide, sodium alginate, sodium stearyl fumarate, talc, sytnetic iron oxides, titanium dioxide Abbott Laboratories... 

El-Kamel, A., Sokar, M., Naggar, V., and A1 Gamal, S. (2002), Chitosan and sodium alginate-based bioadhesive vaginal tablets, AAPS PharmSci, 4, E44. 

Tablet binder Substance used to cause adhesion of powder particles in tablet granulations Acacia, alginic acid, carboxymethylcellulose sodium compressible sugar, ethylcellulose gelatin, liquid glucose, metylcellulose povidone, pregelatinized starch...

Tablet Used in solid dosage forms to Alginic acid,...

Another system was based on a swelling core tablet and a surrounding coating consisting of a combination of hydrophobic and hydrophilic polymers. The insoluble hydrophilic polymer, such as calcium pectinate or calcium alginate, was dispersed in the coating and served as a channel-former in order to control the water penetration. The core contained a swelling, but... 

Disintegrants To facilitate the breakup of a tablet in the gastrointestinal tract Starch and derivatives (polyplasdone XL) Microcrystalline cellulose Clays, algins, gums, surfactants... 

Live rotavirus vaccine was developed for oral delivery to prevent infections by the virus in young children. However, incorporation of live rotavirus into poly (oL-lactide-co-glycolide) microspheres or alginate microcapsules was reported to result in a significant loss of rotavirus infectivity. The loss was reduced by stabilization of the rotavirus vaccine with an excipient blend of cellulose, starch, sucrose, and gelatin at a mass ratio of 30 30 30 10 in granules or tablets. ... 

Alginic acid is used in a variety of oral and topical pharmaceutical formulations. In tablet and capsule formulations, alginic acid is used as both a binder and disintegrating agent at concentrations of 1-5% Alginic acid is widely... 

When using alginic acid in tablet formulations, the alginic acid is best incorporated or blended using a dry granulation process. 

Ammonium alginate is widely used in cosmetics and food products, and also in pharmaceutical formulations such as tablets. It is generally regarded as a nontoxic and nonirritant material, although excessive oral consumption may be harmful. 

In pharmaceutical formulations, calcium alginate and calcium-sodium alginate have been used as tablet disintegrants. The use of a high concentration (10%) of calcium-sodium alginate has been reported to cause slight speckling of tablets. ... 

Khan KA, Rhodes CT. A comparative evaluation of some alginates as tablet disintegrants. Pharm Acta Helv 1972 47 41-50. 

Gursoy A, Cevik S. Sustained release properties of alginate microspheres and tabletted microspheres of diclofenac sodium. ] Microencapsul 2000 17(5) 565-575. 

Yomota C, Miyazaki T, Okada S. Sustained-release effect of the direct compressed tablet based on chitosan and Na alginate. Yakugaku Zasshi 1994 114 257-263. 

Miyazaki S, Nakayama A, Oda M, et al. Drug release from oral mucosal adhesive tablets of chitosan and sodium alginate. Int J Pharm 1995 118 257-263. 

Sakr AM, Elsabbagh HM, Shalaby AH. Effect of the technique of incorporating sodium alginate on its binding and/or disintegrating effectiveness in sulfathiazole tablets. Pharm Ind 1978 40(10) 1080-1086. 

Klaudianos S. Alginate sustained-action tablets [in German]. Dtsch Apoth Ztg 1978 118 683-684. 

Holte O, Onsoven E, Myrvold R. Sustained release of water-soluble drug from directly compressed alginate tablets. Eur ] Pharm Set 2003 20(4-5) 403 07. 

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