Synthesis automation

He is an author of more than 150 papers published in international scientific journals. His scientific interests cover the synthesis of biologically active molecules and the development of new methodologies directed to synthesis automation applied to drug discovery and drug optimization. 

I 2 Supported Reagents and Scavengers in Multi-step Organic Synthesis Automated library synthesis using solid-supported reagents... 

Harness JR, Automation of high-throughput synthesis, Automated laboratory workstations designed to perform and support combinatorial chemistry, In Chaiken IM, Janda KD, eds., Molecular Diversity and Combinatorial Chemistry Libraries and Drug Discovery, ACS Conference Proceedings Series, Washington, DC, American Chemical Society, pp. 188-198, 1996. 

DeWitt SH, Schroeder MC, Stankovic CJ, Czarnik AW, Diversomer technology solid phase synthesis, automation, and integration for the generation of chemical diversity, Drug. Dev. Res., 33 116-124, 1994. 

One must keep in mind, though, that success in synthesis automation requires first and foremost innovative chemistry. PET radiosynthesis draws from a broad chemistry knowledgebase rooted in synthetic organic chemistry [3],... 

The Use of Polymer-Assisted Solution-Phase Synthesis Automation a. 0 n=c=n-r... 

In summary, the synergistic combination of advances in chemical synthesis, automation and purification, coupled with in silico tools and biological target information, has paved the way for the design of more efficiently focused libraries. 

Combinatorial chemistry Library Microarray Solid-phase synthesis Automated synthesis Polymer-supported solution synthesis Tag-assisted solution synthesis High-throughput synthesis... 

Automation and Data Processing 1.5.1 Synthesis Automation and Data Processing... 

Merrifield solid-state peptide synthesis Automated synthesis u.sing polystyrene to anchor a peptide chain. 

Merrifield solid-state peptide synthesis Automated synthesis using polystyrene to anchor a peptide chain. Meso compound A compound with at least two stereocenters yet superimposable on its mirror image. Meta- (m-) Common-name prefix for 1.3-disubstituted benzenes. 

In addition to the above-mentioned, rather painstaking, techniques of polypeptide syntheses, a very elegant technique was developed by Merrifield. This solid-phase peptide synthesis automates the reaction sequences. The method makes use of an insoluble crosslinked polymer substrate with pendant reactive groups for attachment of peptide chains. Chloromethylated polystyrene microgels are often used (see Chapter 8 for more discussions on the use of chloromethylated polystyrene for reactions of polymers). The chloromethyl moieties serve as the initiating sites for formation of the polypeptides ... 

Hardware compilation, high-level synthesis, automated hardware synthesis, attribute grammars, formal synthesis methods, attribute grammar evaluators... 

Peptide Synthesis Automated Peptide Synthesis The Merrifield Solid-Phase Method... 

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