Synthesis polymer-assisted solution phase

Chemically functionalized polymers have also been used in polymer-assisted solution-phase synthesis to perform reaction-quenching functions. These polymers often are used in operations that substitute for traditional liquid-phase extractions in classical synthesis. 

Polymer-assisted solution-phase synthesis offers strategies for chemical library construction that complement solid-phase methods. Tools now available include chemoselective sequestering resins, bifunctional solution-phase linking reagents, bifunctional chemically tagged reagents, and an... 

Thus, isolation of oxoammonium salts on insoluble, cross-linked polymer supports was investigated along with their implementation in polymer-assisted solution-phase synthesis.23 These isolated oxoammonium salts could be employed in a water-free system to generate highly reactive oxidation agents without the overoxidation problems normally seen in the presence of water. 

During the past few years, polymer-assisted solution-phase synthesis has become the prevalent method for the parallel synthesis of chemical libraries as confirmed by the increasing number of publications and reviews on the subject.16-29 A key step in the parallel solution-phase combinatorial... 

A. Kirschning, M. Jesberger, and A. Schonberger, The first polymer-assisted solution-phase synthesis of deoxyglycosides, Org. Lett., 3 (2001) 3623-3626. 

In this chapter we discuss the new speeding-up techniques, optimized during the last decade, such as solid-phase extraction, polymer-assisted solution-phase synthesis, microwave-assisted organic synthesis, and flow chemistry. The improvements obtained with these techniques are not limited to a subset of chemical reactions (e.g., the reported examples), but they are fully applicable to the entire set of chemistry involved in the synthetic drug discovery process. 

MAOS can also be coupled to polymer-assisted solution phase synthesis (PASP, see above). In 2005 a short review of the combination of these two techniques was published [22], gathering some representative examples of the recent literature. 

II. Polymer-assisted solution phase synthesis (PASP synthesis)... 

The Use of Polymer-Assisted Solution-Phase Synthesis and Automation for the High-Throughput Preparation of Biologically Active Compounds... 

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