Sweetening agents saccharin

The sweetening agent saccharin is also derived from a sulphonamide it is prepared from toluene-o-sulphonamide by oxidising the CHs-group to carboxyl with permanganate ring closure is subsequently brought about by the action of concentrated hydrochloric acid ... 

C (decomp.) It is made by the oxidation of toluene-o-sulphonamide with alkaline permanganate. Saccharin has about 550 times the sweetening power of sucrose, and is used extensively as a sweetening agent, usually in the form of the sodium salt. The use of saccharin is restricted in the U.S. 

The isothiazole ring does not occur in nature. By far the most important synthetic isothiazole derivative is saccharin. This was the first non-carbohydrate sweetening agent to be discovered, as long ago as 1879. It is about 300 times as sweet as sucrose, and is still used in many countries as a non-nutritive sweetener. After it was found that administration of massive doses to rats caused bladder cancer, its use was banned in the New World, but the controversy continues as to whether there is any danger when it is used in small quantity. Saccharin is also used as an additive in electroplating processes (73AHC(15)233). 

Siiss-stofF, m. sweet substance sweetening agent, dulcifier, specif, saccharin, -waren, f.pL confectionery, sweete. -wasser, n. fresh water, -wasserablagerung, /. fresh-water deposit, -wein, m. sweet wine. 

Thiophene saccharine (1) is a synthetic sweetening agent with a distinct resemblance to saccharine itself, Imide disconnection shows that we need some derivative of diacid (2). 

Both solid and liquid dosage forms may contain saccharin. Saccharin is a nonnutritive sweetening agent, which is 300 times as sweet as sucrose. In a survey of sweetener content of pediatric medications, seven out of nine chewable tablets contained saccharin (0.45-8.0 mg/tablet) and sucrose or mannitol. Seventy-four of the 150 liquid preparations investigated contained saccharin (1.25-33 mg/5 mL) [62], Saccharin is a sulfanamide derivative that should be avoided in children with sulfa allergies [54],... 

Saccharin, as its formula shows, is acidic in virtue of its imino hydrogen atom. The soluble sweetening agent is the sodium salt. 

In addition to sucrose, a number of other sweetening agents have been utilized in foods and pharmaceuficals over the years, including dextrose, mannitol, sorbitol, aspartame, saccharin, and others. Some sweeteners, such as sucrose, aid in preserving the product. 

Although saccharin is no longer widely use as a non-caloric sweetening agent, it did enjoy a nearly 100-year run before evidence of its animal carcinogenicity appeared on the scene during the 1970s. As... 

Artificial sweeteners such as sorbitol saccharin is used as synthetic sweetening agent which is more palatable having no food value and can be used by diabetic patients. 

If this residue does not taste sweet, the wine does not contain saccharin, but if it has a persistent sweet taste, the presence of an artificial sweetening agent is certain. Saccharin is identified as follows ... 

Disodium edetate Chelating agent Sodium saccharin Sweetening agent... 

Hazemoto et al (1+0) developed an ion-selective electrode sensitive to saccharin, by establishing an ion association between Fe2+-bathophenanthroline chelate and saccharin in nitrobenzene. The electrode developed could measure saccharin ion in presence of other sweetening agents e.g., sucrose, glucose, sodium cyclamate and sorbitol in the concentration range of 10 - - to 10 M. 

Thin layer chromatography has been used in qualitative and quantitative analysis of saccharin, when present in artificial sweetening agents, beverages, food and pharmaceuticals. Several systems have been used and are listed in table 5-... 

Saccharin (1) and its sodium salt (19a) have found extensive use as nonnutritive sweetening agents.81... 

Saccharin is an intense sweetening agent used in beverages, food products, table-top sweeteners, and oral hygiene products such as toothpastes and mouthwashes. In oral pharmaceutical formulations, it is used at a concentration of 0.02-0.5% w/w. It has been used in chewable tablet formulations as a sweetening agent. 

Sodium cyclamate is used as an intense sweetening agent in pharmaceutical formulations, foods, beverages, and table-top sweeteners. In dilute solution, up to about 0.17% w/v, the sweetening power is approximately 30 times that of sucrose. However, at higher concentrations this is reduced and at a concentration of 0.5% w/v a bitter taste becomes noticeable. Sodium cyclamate enhances flavor systems and can be used to mask some unpleasant taste characteristics. In most applications, sodium cyclamate is used in combination with saccharin. 

Saccharin is approximately 300 times as sweet as sucrose but can have a bitter after-taste in concentrated solution it is non-calorific, does not contribute to the problem of obesity or tooth decay, and can be used by diabetics as a sugar substitute. Saccharin is stable to heat and so can be used in cooking. A number of saccharin derivatives, e.g. (88a)-(88e), have been synthesised as potential sweetening agents (Figure 12). 

Trade names Saccharin Sweet n Low Indications Sugar substitute Category Sweetening agent Half-life N/A... 

Saccharin s use as a sweetening agent has just achieved its centenary. During the 1970s the alleged carcinogenicity in humans of saccharin was the subject of a prolonged controversy. The interested reader should refer to one of the excellent summaries written by Lepkowski.6... 

Synod. [PMC Spedalties] Saccharin < -salts sweetening agents for foods, tootli astes, cosmetics, pharmaceuticals. 

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