Sweetening agents saccharin sodium

C (decomp.) It is made by the oxidation of toluene-o-sulphonamide with alkaline permanganate. Saccharin has about 550 times the sweetening power of sucrose, and is used extensively as a sweetening agent, usually in the form of the sodium salt. The use of saccharin is restricted in the U.S. 

Saccharin, as its formula shows, is acidic in virtue of its imino hydrogen atom. The soluble sweetening agent is the sodium salt. 

Disodium edetate Chelating agent Sodium saccharin Sweetening agent... 

Hazemoto et al (1+0) developed an ion-selective electrode sensitive to saccharin, by establishing an ion association between Fe2+-bathophenanthroline chelate and saccharin in nitrobenzene. The electrode developed could measure saccharin ion in presence of other sweetening agents e.g., sucrose, glucose, sodium cyclamate and sorbitol in the concentration range of 10 - - to 10 M. 

Saccharin (1) and its sodium salt (19a) have found extensive use as nonnutritive sweetening agents.81... 

Saccharin sodium is an intense sweetening agent used in beverages, food products, table-top sweeteners, and pharmaceutical formulations such as tablets, powders, medicated confectionery, gels, suspensions, liquids, and mouthwashes see Table 1. It is also used in vitamin preparations. 

Sodium cyclamate is used as an intense sweetening agent in pharmaceutical formulations, foods, beverages, and table-top sweeteners. In dilute solution, up to about 0.17% w/v, the sweetening power is approximately 30 times that of sucrose. However, at higher concentrations this is reduced and at a concentration of 0.5% w/v a bitter taste becomes noticeable. Sodium cyclamate enhances flavor systems and can be used to mask some unpleasant taste characteristics. In most applications, sodium cyclamate is used in combination with saccharin. 

Saccharin sodium Flavouring agent (sweetener) No range... 

Saccharin is a crystalline, virtually water-insoluble compound of mp 244°C. As its water-soluble sodium salt, it is used as a sweetening agent [112]. It is 300 to 500 times as sweet as saccharose, but has a bitter-metallic aftertaste. 

The chlorosulfonation of toluene by treatment with excess chlorosulfonic acid yields a mixture of the ortho and para sulfonyl chlorides, but the mixture may be separated by freezing out the solid p-isomer (see Chapter 4, p 37). Saccharin 25 contains an acidic hydrogen atom and is generally formulated as the sodium salt to increase water solubility. It is some 300 times sweeter than sucrose and is non-calorific so can be used by diabetics as a sugar substitute. A number of saccharin derivatives have been synthesized as potential sweetening agents (Chapter 6, ref. 33). 

Other Uses. Other appHcations for sodium nitrite include the syntheses of saccharin [81-07-2] (see Sweeteners), synthetic caffeine [58-08-2] (22), fluoroaromatics (23), and other pharmaceuticals (qv), pesticides (qv), and organic substances as an inhibitor of polymerization (24) in the production of foam blowing agents (25) in removing H2S from natural gas (26) in textile dyeing (see Textiles) as an analytical reagent and as an antidote for cyanide poisoning (see Cyanides). 

Many excipients have been associated with adverse reactions in those ingesting drugs and vitamin/mineral formulations containing these compoundsJ78 79 Antioxidants (e.g., sodium sulfite, sodium and potassium bisulfites, and metabisulfites), bacterial preservatives (e.g., benzyl alcohol and benzalkonium chloride), artificial sweeteners (e.g., aspartame and saccharine), coloring agents (e.g., FD C yellow 5, blue 2, and red 40), and propylene glycol. A few examples of the toxic effects of these follow. 

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