Supplementary Data

Measurements have been made in a static laboratory set-up. A simulation model for generating supplementary data has been developed and verified. A statistical data treatment method has been applied to estimate tracer concentration from detector measurements. Accuracy in parameter estimation in the range of 5-10% has been obtained. 

Both multiple-tube and membrane-filter methods are also available for testing for the fecal streptococcal group (20). These assays can be used to provide supplementary data regarding the bacteriological quaUty of water. Other fecal indicators should also be used concurrendy because of the survival characteristics of the fecal streptococci. 

Tables with quantitation results for all control samples should be presented as supplementary data only and statements similar to

Supplementary data associated with this article can be found, in the online version, at http //dx.doi.Org/10.1016/j.ijms.2012.03.007. 

An outline of the data from non-clinical studies must be submitted to the PMDA with the protocol for the proposed clinical study before commencing the clinical trial. A notification is required for each protocol. The list of items required for Clinical Trial Plan Notification is shown in Table 23.4. Furthermore, supplementary data must be added on entry to subsequent clinical phases, that is, general clinical trials and comparative trials. Such data are reviewed by the PMDA, and for this purpose the sponsor must wait for 30 days after submitting the initial notification before executing a contract with the medical institute. For a subsequent notification, the review period is reduced to 14 days. The notification also... 

Two classes of new data may be submitted after an application has been accepted - additional data and supplementary data. Additional data are data identified at a pre-submission meeting that TGA agrees to accept during the course of an evaluation at a predetermined date, such as the results from an ongoing clinical study. 

Supplementary data are clinical or preclinical data submitted at the initiation of the sponsor, after it has received either or both of the Module 4 and Module 5 evaluation reports. The sponsor must notify its intention to submit supplementary data within five working days of receipt of the last evaluation report. Only one submission of supplementary data is permitted for each of Modules 4 and 5, unless otherwise agreed by TGA in writing. Supplementary data will not be accepted after commencement of the pre-ADEC process, which is signified by the issuing of the delegates overview and recommendation. Acceptance of supplementary data is at the discretion of the TGA and is dependent upon mutual agreement to a clock stop. ... 

Up to 60 working days is allowed for all additional data and fees to be presented to the TGA following the sponsor s notification of intent and up to 135 days may be taken for evaluation of the supplementary data after all data and fees have been received by TGA. 

In addition to Appendix A providing Supplementary Data in support of several chapters in Section II, Appendix B provides a glossary of Common Terms and Acronyms associated with molecular mechanics and quantum chemical models. 

K value was estimated from measured aqueous and sediment eoneentrations in 30 Duteh har-hours evenly distributed over the Netherlands. This resulted in an average value of 5.34 (see also the supplementary data). This outcome is within the range of reported values from the... 

Supplementary data are given in Appendix A, pp 35-44. These include Tables Al, A2,... 

D. W. Dodge, G. L. Houghton, R. E. Otto, R. L. Pigford, Sidney Rankin, and R. D. Vaughn contributed directly to the final manuscript. Many of the authors of work reviewed in this chapter supplied supplementary data, figures, and calculations to enable more detailed analysis and comparison of various sources of information than would otherwise have been possible. 

Test objectives and prerequisites Responsibilities and signatories Test or verification method Traceability to specified requirements Test data collection and record Deviation procedure Test procedure Test data sheets Qualification review and report Supplementary data sheets... 

Toxaphene TMF calculated from mean values given by Stapleton et al. [138] in supplementary data for their paper and for PCBs from Fig. 6 in their paper... 

Look at the highly effective result. You have ample room for notes, a left hand margin for special emphasis items or inserting supplementary data from the textbook, a large area at the bottom for a brief summary, and a little rectangular space for just about anything you want. 

The analysis of the products called for supplementary data on the decreases in vapor pressure produced by low temperature baths. After removal of hydrobromic acid, ethylene and unsaturated compounds the residual gas was subjected in different cooling baths to the temperatures listed in Table V and the cor-... 

Other supplementary data (e.g., water solubility, vapor pressure, and molecular weight)... 

Parameters have been obtained from supplementary data via the Cambridge Crystallographic Data Center when not listed in published work. Parameters quoted are for molecules on general positions of 12 molecules in the unit cell, 8 are on general and 4 on special positions. 

Figure 2.3 International comparison of median ( mean) concentrations of summed BDE congeners ( ig/kg lipid weight) in human milk. After Toms et al., 2007, with supplementary data. Data are taken from Baumann et al., 2003 Bi et al., 2006 Bordajandi, Abad and Gonzalez, 2008 Darnerud et al., 2002 Esiami et al., 2006 Fangstrom et al., 2004 Furst, 2006 Jaraczewska et al., 2006 Kalantzi et al., 2004 Ryan et al., 2002 Schechter et al., 2003, 2006 Strandman, Koistinen and Vartiainen, 2000 Sudaryanto et al., 2005 Toms et al., 2007 Tsydenova et al., 2007...

Table 1 Major groups of mantle xenoUths in kimberUte-related and alkali basalt series volcanic rocks (after Harte and Hawkeswortb, 1989). Textural classification follows that of Harte (1977). Terminology for phlogopite-rich mafic mantle xenoUths from Gregoire et al. (2002). For supplementary data and classifications see Nixon (1987), table 62. 

In general terms, additional data may not be submitted once an application has been accepted for evaluation, unless specifically asked to do so on a Section 31 request. However, in some instances there is an opportunity to submit additional data that is identified at the time of the initial application, or at a pre-submission meeting. In such cases, the TGA has the discretion to accept this additional data for evaluation and it is possible that an extended evaluation time may be applied. There are also limited opportunities to submit supplementary data, at the initiation of the sponsor, to address deficiencies that may have been identified in the TGA s assessment of the dossier. In these cases, mutual agreement to stop the clock is essential, and further evaluation fees may also be levied. 

Toxicological Sciences, the official SOT journal, is distributed monthly in print and electronically. The journal publishes premier peer-reviewed, hypothesis-driven, original research articles that are broadly relevant to assessing the potentially adverse health effects resulting from exposure of humans or animals to chemicals, drugs, natural products, or synthetic materials. Studies may involve experimental animals or human subjects, or they may focus on in vitro methods or alternatives to the use of experimental animals. Sections include original research, reviews, forum articles on policy or research issues, editorials, letters to the editor, and supplementary data guidelines. 

Trace analysis and the move to the use of smaller sample sizes represent particular challenges in that the ratio of surface area exposure to sample volume, or quantity of analyte, is increased, multiplying the possible effect and level of contamination. While mass spectral identification of contaminants will aid in identifying their source (see the literature-derived Excel database of contaminant mass spectra in the supplementary data of Keller et al 12), this is not essential. The key tool to their elimination is the appropriate use of sample blanks at each step of the analytical protocol during method development and validation. 

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