Superporous hydrogels

Swelling Kinetics of Hydrogels Hydrogels, Microporous Hydrogels, and Macroporous Hydrogels Superporous Hydrogels (SPHs)... 

Figure 2 Representations of a superporous hydrogel (A) and a conventional hydrogel (B) in the dried state. No porous structures are observable in conventional hydrogels by a scanning electron microscope. 

Stomach 0.2 1-3 1.5-5 Enteric coating may be required for drugs that are sensitive to acidic conditions. If the stomach is the target region for absorption, superporous hydrogels may be used for gastroretention... 

Omidian H, Rocca JG, Park K. Advances in superporous hydrogels. J Control Release 2005 102(1) 3—12. 

Gemeinhart, R.A., H. Park, and K. Park. 2001. Effect of compression on fast swelling of poly(acrylamide-co-acrylic acid) superporous hydrogels. J Biomed Mater Res 55 54. 

Chen, J., et al. 2000. Gastric retention properties of superporous hydrogel composites. J Control Release 64 39. 

Tang, C., et al. 2005. New superporous hydrogels composites based on aqueous Carbopol solution (SPHCcs) synthesis, characterization and in vitro bioadhesive force studies. Eur Polym J 41 557. 

Dorkoosh, F.A., Verhoef, J.C. Verheijden, J.H.M., Rafiee-Tehrani, M., Borchard, G. and Junginger, H.E. (2002) Peroral absorption of octreotide in pigs formulated in delivery systems on the basis of superporous hydrogel polymers. Pharm. Res. 19 1532-1536. 

Chen, J. Park, K. Synthesis and characterization of superporous hydrogel composites. J. Control. Release 2000, 65, 73-82. 

Omidism H, Park K. Experimental design for the synthesis of polyacrylamide superporous hydrogels. J Bioact Compat Polym 2002 17 433-450. 

Yang SY, Fu Y, Jeong SH, Park K. Application of polyCacrylic acid) superporous hydrogel microparticles as a super-disintegrant in fast-disintegrating tablets. J Pharm Pharmacol 2004 56 429-436. 

Park K. Superporous hydrogels for pharmaceutical and other applications. Drug Delivery Technol 2002 2 38-44. 

Reppas, N.A. Hydrogels and drug delivery. Curr. Opin. Colloid Interface Sci. 1997, 2 (5), 531-537. Chen, J. Rark, H. Rark, K. Synthesis of superporous hydrogels Hydrogels with fast swelling and superabsorbent properties. J. Biomed. Mater. Res. 1999,44 (1), 53-62. 

Superporous hydrogels (SPHs) ate materials developed to demonstrate fastswelling and superabsorbent properties (Omidian et al., 2005). These were initially proposed as gastric retention devices however, SPHs may be tailor-made for other applications in pharmaceutical arxl biomedical industries (Omidian et al., 2007). The high swelling pressure of SPHs can potentially be used to trigger an alarm system upon the incursion of water and hence, can be utilized as smart hydrogels or sensors for various apphcations. 

---