Gastric retention

Multi-particulate dosage forms will empty more slowly in the presence of food than in the fasted state. Since the dosage 

We also conducted a combined scintigraphy and pharmacokinetic study in healthy volunteers, which allowed comparison of the in vivo rates of disintegration and gastric emptying 

---

Gastric Retention of Enzyme-Digestible Hydrogels in the Canine Stomach under Fasted and Fed Conditions... 

Over the course of these experiments, if gastric retention in the fasted state was observed for 24 h, the animal was given a standard pelletized meal once-a-day. The purpose for this was to observe the effects of food on hydrogel retention and also to determine if the presence of the gel had any effect on inhibiting the transit of food. 

In summary, the advantages of our approach to studying gastric retention are twofold. First, hydrogel response to the gastric environment can be noninvasively visualized in real-time. Second, a more efficient and justifiable approach to the development of long-term oral drug delivery systems can be achieved. 

Tablets fast dissolving, lipid-carrier based, slow releasing, disintegrate without water, float in the stomach (gastric retentive), buccal... 

Hwang, S.J., Park, H., and Park, K., Gastric retentive drug-delivery systems, Crit. Rev. Ther. Drug Carr. Syst., 15 243-284 (1998). 

Gi disorders Doses administered to patients with ulcerative colitis may suppress Gl motility and produce paralytic ileus and precipitate or aggravate toxic megacolon. Administer ER tablets with caution to patients with Gl obstructive disorders because of the risk of gastric retention. 

Urinary retention gastric retention uncontrolled narrow-angle glaucoma hypersensitivity to the drug or its ingredients. 

In patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions known hypersensitivity to the drug or its ingredients. 

Gl obstruction gastric retention bowel perforation toxic colitis, megacolon, or ileus. 

Pyloric stenosis Patients with pyloric stenosis may have prolonged gastric retention of balsalazide capsules. 

Contraindications Gastric retention, uncontrolled angle-closure glaucoma, urine retention... 

---