Sulfated fucan

Marine sulfated polysaccharides (MSPs), such as sulfated fucans (SFs), sulfated galactans (SGs), and glycosaminoglycans (GAGs) isolated from invertebrate animals, are highly anionic polysaccharides capable of interacting with certain cationic proteins, such as... 

Becker, C. F., Guimaraes, J. A., Mourao, P. A., and Verli, H. (2007). Conformation of sulfated galactan and sulfated fucan in aqueous solutions Implications to their anticoagulant activities. ]. Mol. Graph. Model. 26, 391-399. 

Berteau, O. and Mulloy, B. (2003). Sulfated fucans, fresh perspectives Structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 13, 29R-40R. 

Mourao, P. A. (2004). Use of sulfated fucans as anticoagulant and antithrombotic agents Future perspectives. Curr. Pharm. Design 10, 967-981. 

Mourao, P. A. and Pereira, M. S. (1999). Searching for alternatives to heparin Sulfated fucans from marine invertebrates. Trends Cardiovasc. Med. 9, 225-232. 

Mulloy, B., Ribeiro, A. C., Alves, A. P., Vieira, R. P., and Mourao, P. A. (2004). Sulfated fucans from echinoderms have a regular tetrasaccharide repeating unit defined by specific patterns of sulfation at the 0-2 and 0-4 positions. J. Biol. Chem. 269, 22113-22123. 

Pereira, M. S., Melo, F. R., and Mourao, P. A. (2002a). Is there a correlation between structure and anticoagulant action of sulfated galactans and sulfated fucans Glycobiology 12, 573-580. 

Pomin, V. H. and Mourao, P. A. (2008). Structure, biology, evolution, and medical importance of sulfated fucans and galactans. Glycobiology 18,1016-1027. 

Yoon, S. J., Pyun, Y. R., Hwang, J. K., and Mourao, P. A. (2007). A sulfated fucan from the brown alga Laminaria cidwrioides has mainly heparin cofactor 11-dependent anticoagulant activity. Carbohydr. Res. 342, 2326-2330. 

Sulfated fucan from brown seaweed shows anti-complementary activity by inhibition of the complement system [67]. The polysaccharide has been found to inhibit C4 cleavage which results in the formation of the classical C3 convertase (C4b2a), and to inhibit formation and function of alternative C3 convertase (C3bBb) by interfering with the binding of factor B to C3b and accelerating the decay of factor P-stabilized sites on the alternative C3 convertase (Fig. 7) [67]. 

Pereira, M.S. etal. (1999) Structure and anticoagulant activity of sulfated fucans. Comparison between the regular, repetitive, and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae. / Biol. Chem. 274, 7656-7667... 

Anaslyuk, S.D., Shevchenko, N.M., Nazarenko, E.L., Imbs, T.I., Gorbach, V.I., Dmitrenok, P.S., and Zvyagintseva, T.N. (2010) Structural analysis of a highly sulfated fucan from the brown alga Laminaria cichorioides by tandem MALDI and ESI mass spectrometry. Carbohydr. Res., 345, 220-2212. 

For a recent sruvey on all physico-chemical and biological aspects of fucoidans and sulfated fucans, see Berteau and Mulloy (2003) and Cumashi et al. (2007). 

G., and Mourao, PA.S. (2005) Selective cleavage and anticoagulant activity of a sulfated fucan stereospedfic removal of a 2-sulfate ester from the polysaccharide by mild add hydrolysis, preparation of oligosaccharides, and heparin cofaclor 11-dependent anticoagulant activity. Glycobiology, 15, 369-381. 

Tissot, B. and Daniel, R. (2003) Biological properties of sulfated fucans the potent inhibiting activity of algal fucoidan against the human complement system. Glycobiology, 13, 29G-31G. 

Figure 26.9 Comparative structures of sulfated fucans of brown algae, the echinid Lytechinus vari atus, and the holothurian Ludivigothurea grisea.

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