Substance abuse methamphetamine

Srisurapanont M, Jarusuraisin N, Kittirattanapaiboon P Treatment for amphetamine dependence and abuse. Cochrane Database Syst Rev 4 CD003022, 2001 Srisurapanont M, Ali R, Marsden J, et al Psychotic symptoms in methamphetamine psychotic in-patients. Int J Neuropsychopharmacol 6 347-352, 2003 Substance Abuse and Mental Health Services Administration Overview of Findings From the 2002 National Survey on Drug Use and Health (DHHS Publ No SMA 03-3774). Rockville, MD, Substance Abuse and Mental Health Services Administration, 2003... 

The DRD2 and ANKK1 genes are located approximately 10,000 nucleotides apart on chromosome llq22-23. Variants in both genes have been found to be associated with several psychiatric diseases such as schizophrenia, as well as with substance abuse disorders, including alcohol, heroin, nicotine, cocaine, opioid, gambling, methamphetamine, and polysubstance addiction [30-37]. 

Innovative research is also ongoing to characterize natural product-derived substances that prevent the gastrointestinal absorption of alcohol, and limit CNS receptor super-sensitivity responses to chronic methamphetamine abuse. Development of pharmacologic treatments that could effectively and safely achieve either goal would be of enormou spotential consequence in the management of two of the most intractable and costly substance abuse problems in the U.S, namely alcoholism and methamphetamine abuse. 

Is the nicotine patch an effort to modify human mental activity Will a brain Polypill be developed to treat persons susceptible to substance abuse, such as cocaine We now know that cocaine and methamphetamine flood the brain with dopamine and other neurotransmitters,producing a"high. Methamphetamine (meth),prescribed for patients with severe attention-deficit hyperactivity disorder or narcolepsy, is widely abused. Crystal meth is the crystalline form of the drug that is smoked. It is difficult to imagine that there will ever be supplementation of a communal water supply, but we should remember that salt is iodized, there is fluoride in water and iron and folic acid are supplements in many foods. 

Ricaurte GA, McCann UD, Szabo Z, et al Toxicodynamics and long-term toxicity of the recreational drug 3,4-methylenedioxy-methamphetamine (MDMA, Ecstasy ). Toxicol Lett 112-113 143-146, 2000 Robinson TN, Killen JD, Taylor CB, et al Perspectives on adolescent substance use a defined population study. JAMA 258 2072-2076, 1987 Rubinstein JS Abuse of antiparkinson drugs feigning of extrapyramidal symptoms to obtain trihexyphenidyl. JAMA 239 2365, 1978 Rumack BH (ed) LSD, in Poisindex, Vol 54. Denver, CO, Micromedex, 1987 Rusyniak DE, Banks ML, Mills EM, et al Dantrolene use in 3,4-methylenedioxymethamphetamine ( ecstasy )-medicated hyperthermia (letter). Anesthesiology 10 263, 2004... 

Schedule II—The drug or other substance has (1) a high potential for abuse, (2) a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (3) abuse of the drug or other substances may lead to severe psychological or physical dependence. Examples cocaine, PCP, morphine, fentanyl and meperidine, codeine, amphetamine and methamphetamine, Ritalin . 

That impression gets of a lot of routine reinforcement from news sources. Chemistry is associated with pollution of the atmosphere by ozone and the noxious oxides of nitrogen and sulfur, oil spills, toxic pesticides and herbicides, smelly oil refineries, undesired food additives, chemical accidents, substances of abuse such as heroin, cocaine, and methamphetamine, and chemical weapons. Chemistry gets a lot of bad ink. 

Substance-Induced Anxiety Disorder. Numerous medicines and drugs of abuse can produce panic attacks. Panic attacks can be triggered by central nervous system stimulants such as cocaine, methamphetamine, caffeine, over-the-counter herbal stimulants such as ephedra, or any of the medications commonly used to treat narcolepsy and ADHD, including psychostimulants and modafinil. Thyroid supplementation with thyroxine (Synthroid) or triiodothyronine (Cytomel) can rarely produce panic attacks. Abrupt withdrawal from central nervous system depressants such as alcohol, barbiturates, and benzodiazepines can cause panic attacks as well. This can be especially problematic with short-acting benzodiazepines such as alprazolam (Xanax), which is an effective treatment for panic disorder but which has been associated with between dose withdrawal symptoms. 

Although amphetamines use in Africa remained stable, abuse of methamphetamine is rapidly increasing in South Africa. In Cape Town, methamphetamine accounted for less than 1 per cent of all substance related treatment demand by the end of 2002, but this has risen since and over the first two quarters of 2006, the proportion amounted to 37 per cent. In other parts of the country, while abuse remains far lower, small increases could still be noted. For all the locations cov-... 

Fig. 138 Cape Town (South Africa) proportion of methamphetamine as primary substance of abuse in treatment, 2000-2006...

The abuse of marketed medications has been at the forefront of public awareness in recent years, mostly due to widespread reports concerning OxyContin and hydrocodone.1 While these are highly regulated, prescription-only medications with recognized potential for abuse, even some over-the-counter (OTC) medications have become problematic, either because of their own effects (e.g., ephedrine) or because they are used in the manufacture of other abused substances (e.g., pseudoephedrine, used to make methamphetamine).2 3... 

When discussing the mental and psychological effects of methamphetamine, it is useful to examine the two main types of abuse patterns of this substance, since each pattern has distinct psychological consequences. The two main abuse patterns of methamphetamine are low-intensity use and binge, or high-intensity use. 

Stimulant drugs commonly abused in the USA include methamphetamine ("crank," "crystal"), methylenedioxymethamphetamine (MDMA, "ecstasy"), and cocaine ("crack") as well as legal substances such as pseudoephedrine (Sudafed) and ephedrine (as such and in the herbal agent Mar-... 

Since 1971, the DEA, the agency responsible for the regulation and control of substances with potential for abuse, has classified Ritalin in the Schedule II category of drugs, together with cocaine, amphetamines, methamphetamine... 

In conclusion, animal studies have shown that MPH has an abuse liability similar to that of other Schedule II stimulants, including amphetamine, methamphetamine, and cocaine. Actual data on abuse indicate that the pattern of MPH abuse is similar to that of other potent psychostimulants and that MPH is diverted and abused to a similar extent as other pharmaceutical Schedule II substances. Taken collectively, the data indicate that MPH fits the profile of a Schedule II substance. 

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