Sublingual tablets

Oral mucosal membranes provide a port for systemic therapy as weU. Nitroglycerin sublingual tablets (Nitrostat) abort acute mgina attacks methyl-testosterone [58-18-4] buccal tablets (Android 5) are indicated for testosterone [58-22-0] replacement therapy (39) md nicotine [54-11-5] gum (Nicorette) aids in smoking cessation. 

Check the expiration date on die container of sublingual tablets. If the expiration date has passed, do not use die tablets. Instead, purchase a new supply. Unused tablets should be discarded 6 months after die original bottle is opened. 

Gu X, Simons KJ, Simons FER Administration by sublingual tablet feasible for the first aid treatment of anaphylaxis A proof-of-concept study. Diophar Drug Dispos 2002 23 213-216. 

Gertain drugs are administered as sublingual tablets (they are placed under the tongue) and as rectal suppositories these substances can be absorbed in the mouth and rectum, respectively. 

Currently approved NRT products include the transdermal nicotine patch and several acute NRT products, including nicotine gum, lozenge, sublingual tablet, vapor inhaler, and nasal spray. The single-dose nicotine plasma curves for transdermal patch, gum, nasal spray, lozenge, as well oral snuff and a cigarette, are illustrated in Fig. 1 (note for the sake of simphcity, the curve for sublingual tablet is not illustrated, but because of the route of nicotine delivery, the plasma curve is qualitatively similar to nicotine gum). 

A small sublingual nicotine tablet has been developed and is currently being marketed in many European countries, but is not yet available in the USA. The product is designed to be held under the tongue, where the nicotine is absorbed sublingually over about 30 min. The product that is currently available contains 2 mg nicotine, of which 1 mg is absorbed via the buccal mucosa. Compared to the gum and lozenge, the sublingual tablet demands even less activity from the user. The levels of nicotine obtained by use of the 2-mg tablet and 2-mg nicotine gum are similar (Molander and Lunell 2001). 

Suboxone is a combination of buprenorphine (opioid partial agonist) and naloxone. It is presented as sublingual tablets and is used as an adjunct in the treatment of opioid dependence and in premedication or perioperative analgesia. A side-effect of opioids is drowsiness. 

Angina pectoris - Usual starting dose is 2.5 to 5 mg for sublingual tablets. Titrate upward until angina is relieved or side effects limit the dose. 

Acute prophylaxis - A patient anticipating activity likely to cause angina should take 1 sublingual tablet (2.5 to 5 mg) approximately 15 minutes before the activity is expected to begin. 

Patients who are using certain drugs for erectile dysfunction (eg, sildenafil citrate), because these drugs have been shown to potentiate the hypotensive effects of organic nitrates (sublingual tablets, lingual spray, transdermal). 

Patients with early Ml, severe anemia, increased intracranial pressure, known hypersensitivity to nitroglycerin (sublingual tablets). 

The usual starting dose is 1 mg 3 times/day. Alleviation of symptoms usually is gradual results may not be observed for 3 to 4 weeks. Doses up to 4.5 to 12 mg/day have been used. Up to 6 months of treatment may be necessary to determine efficacy, using doses of 6 mg/day or more. Do not chew or crush sublingual tablets. 

Nitroglycerin by sublingual tablet (0.4 mg) every 5 minutes for a total of 3 doses will be used for ischemic discomfort relief. Intravenous injection will be considered when the ischemic discomfort, hypertension or pulmonary congestion cannot be controlled. Nitrates should not be used when the blood pressure is lower than 90 mmHg or 30 mmHg lower than a known base line value, bradycardia less than 50 bpm, tachycardia more than 100 bpm or suspected right ventricular (RV) infarction. 

May cause transient Gl disturbances allow sublingual tablets to completely dissolve under tongue do not chew or crush sublingual tablets... 

Tolerance may occur with repeated, prolonged therapy, but may not occur with the extended-release form. Minor tolerance maybe seen with intermittent use of sublingual tablets. 

Nitroglycerine 10a is both a drug and an explosive. Its inclusion into the cavity of p-cyclodextrin, p-CD, 11 prevents its decomposition and enhances its bioavailability [14]. The complex of 10a with 11 is marketed under the name Nitropen as a coronary dilator sublingual tablets by Nippon Kayaku company in Japan. 

Oral sublingual tablets or spray, 0.4 mg for acute chest pain. Sustained-release patches give 0.4-0.8 mg-h-1. 

The hepatic first-pass effect can be avoided to a great extent by use of sublingual tablets and transdermal preparations and to a lesser extent by use of rectal suppositories. Sublingual absorption provides direct access to systemic—not portal—veins. The transdermal route offers the same advantage. Drugs absorbed from suppositories in the lower rectum enter vessels that drain into the inferior vena cava, thus bypassing the liver. However, suppositories tend to move upward in the rectum into a region where veins that lead to the liver predominate. Thus, only about 50% of a rectal dose can be assumed to bypass the liver. 

Oral 2, 8 mg sublingual tablets Parenteral 0.3 mg/mL for injection Butorphanol (generic, Stadol)... 

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