Buccal tablets

B. typhosus Bubble Breaker Bubble jet technology Bubble memory devices Bubble packs Bubble-point test Bubble shapes Bubbling-bed design Buccal tablets Bucherer-Bergs reaction Bucherer reaction Bucherer synthesis Bucidovir [86304-28-1]... 

Oral mucosal membranes provide a port for systemic therapy as weU. Nitroglycerin sublingual tablets (Nitrostat) abort acute mgina attacks methyl-testosterone [58-18-4] buccal tablets (Android 5) are indicated for testosterone [58-22-0] replacement therapy (39) md nicotine [54-11-5] gum (Nicorette) aids in smoking cessation. 

Promoting an Optimal Response to Therapy N URATES The nitrates may be administered by die sublingual (under die tongue), buccal (between the cheek and gum), oral, IV, or transdermal route Nitroglycerin may be administered by die sublingual, buccal, to peal, transdermal, oral, or IV route If die buccal form of nitroglycerin has been prescribed, die nurse instructs die patient to place die buccal tablet between die cheek and gum or between die upper lip and gum above die incisors and allow it to dissolve The nurse shows the patient how and where to place die tablet in die mouth. Absorption of sublingual and buccal forms is dependent on salivary secretion. Dry mouth decreases absorption. 

Buccal tablets—Place the tablet between die cheek and molars and allow it to dissolve in die mouth. 

Androgens are important for general sexual function and libido, but testosterone supplementation is only effective in patients with documented low serum testosterone levels. In patients with hypogonadism, testosterone replacement is the initial treatment of choice, as it corrects decreased libido, fatigue, muscle loss, sleep disturbances, and depressed mood. Improvements in ED may occur, but they should not be expected to occur in all patients.23 The initial trial should be for 3 months. At that time, re-evaluation and the addition of another ED therapy is warranted. Routes of administration include oral, intramuscular, topical patches or gel, and a buccal tablet. 

A. A., Ozalp, M., Wilson, C. G., Formulation of a bioadhesive bilayered buccal tablet of natamydn for oral candidiasis, Proc. Inti. Symp. Control. Rd. Bioact. Mater. 2000, 27, 8205. 

C. G., Scintigraphic studies on the in vivo dissolution of a buccal tablet, in ... 

Transmucosal (Actiq Lozenge) 200 meg may repeat x l, 30 minutes after first dose is started, then titrate Transmucosal (Fentora Buccal Tablet) 100 meg, may repeat x l, 30 minutes after first dose is started, then titrate... 

Darwish M, Kirby M, Robertson P, Tracewell W, and Jiang JG (2006) Pharmacokinetic properties of fentanyl effervescent buccal tablets A phase I, open-label, crossover study of single dose 100, 200, 400, and 800 micrograms in healthy adult volunteers. Clin. Ther. 28 707-714. 

Portenoy RK, Taylor D, Messins J, and Tremmel L (2006) A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer. Clin. J. Pain 22 805-811. 

Bouckaert et al. [42] tested buccal tablets of miconazole based on modified starch-polyacrylic acid mixtures. Although these tablets showed different mucoadhe-sion properties in vitro, no significant differences in the salivary content of miconazole could be observed in human volrmteers. 

The term bioadhesion ean be defined as the ability of a material (synthetic or natural) to stick (adhere) to a biological tissue for extended periods of time [27]. The phenomenon of bioadhesion can be visualized as a two-step process. The first step involves the initial contaet between polymer and the biological tissue. The second step is the formation of seeondary bonds due to noncovalent interactions. The strength of bioadhesion (expressed as the foree of detachment) for a novel oligosaccharide gum Hakea Gibbosa) contained in a buccal tablet developed by Alur et al. [28,29]... 

FIG. 3. The force of detachment from excised rabbit intestinal mucosa for directly compressed buccal tablets which contained 40 mg CPM (chlorpheniramine maleate) and 0, 2, 12, 22, and 32 mg Hakea applied to the mucosa with a force of 5 N (— —), 10 N (—0—), 15 N (—O—), and 20 N (—A—). All data points represent the mean value standard deviation of ten experiments. Lines through mean values are included to illustrate the trend and represent a mathematical fit of the data as well (from Ref. 29). 

Do not swallow buccal tablets, allow to dissolve between cheek and gum... 

Avoid eating, drinking, or smoking while buccal tablet in place... 

Place buccal tablets under upper lip or between cheek and gum, let dissolve slowly over 3 5 min, do not chew or swallow... 

Buccal tablets Tablets containing a bioadhesive for locating... 

Oral 10, 25 mg tablets 10 mg capsules 10 mg buccal tablets Nandrolone decanoate (generic)... 

A request for a waiver of in vivo B A/BE studies based on the BCS is not appropriate for dosage forms intended for absorption in the oral cavity (e.g., sublingual or buccal tablets). 

Buccal testosterone tablets provide sustained release of testosterone and also bypass first-pass metabolism in the liver. Small-scale work with a bioadhesive buccal tablet of testosterone has shown that adequate serum concentrations can be obtained and that the buccal tablet (administered twice daily) is well tolerated (102). Other work has confirmed that twice-daily buccal application is optimal to maintain therapeutic serum concentrations of testosterone and its metabolites (103-105) however, it appears that about one patient in six initially has a degree of oral discomfort from the presence of the mucoadhesive tablet, although this fades after a few days and does not seriously affect compliance. Common adverse effects of buccal testosterone include gum irritation, pain, and tenderness, and edema (106) and headache (107). 

Recently a study investigated different types of mucoadhesive polymers for buccal tablet formation [80]. The polymers used were Carbopol (CP934 and CP940), PCP, sodium... 

Nafee, N.A., et al. 2004. Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation. Drug Dev Ind Pharm 30 985. 

Oral sustained-release (generic, Nitrong) 2.6, 6.5, 9 mg tablets 2.5, 6.5, 9, 13 mg capsules Buccal (Nitrogard) 2, 3 mg buccal tablets... 

Khanna R, Agarwal S, Ahuja A. 1996. Preparation and evaluation of bioerodible buccal tablets containing clotrimazole. Int. J. Pharm. 138 67-73. 

Suscard Buccal tablets are formulated so that the drug particles are entrapped within a meshwork of cellulose fibres. On contact with the moist mucosa the outer layer of the tablet hydrates and swells, becoming gel-like in consistency. This has the dual effect of ... 

Nitroglycerin (NTC) is distinguished by a high membrane penetrability and very low stability. It is the drug of choice in the treatment of angina pectoris attacks. For this purpose, it is administered as a spray, or in sublingual or buccal tablets for transmucosal delivery. The onset of action is between 1 and 3 minutes. Due to a nearly complete presystemic elimination, it is poorly suited for oral administration. Transdermal delivery (nitroglycerin patch) also avoids presystemic elimination. 

Giunchedi, E, Juliano, C., Gavini, E., Cossu, M., and Sorrenti, M. (2002), Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres, Eur. I. Pharm. Biopharm., 53,233-239. 

The most common medication for angina is GTN this is available as buccal tablets, sprays or skin patches. Calcium channel blockers and beta-blockers are also effective anti-anginal agents. 

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