Absorption sublingual

Absorption/Distributton - Gl and sublingual absorption of ergotamine is incomplete and erratic following oral administration, peak blood levels are reached in about 2 hours. Following intranasal administration, however, the mean bioavailability of dihydroergotamine mesylate is 32% relative to the injectable administration. 

The hepatic first-pass effect can be avoided to a great extent by use of sublingual tablets and transdermal preparations and to a lesser extent by use of rectal suppositories. Sublingual absorption provides direct access to systemic—not portal—veins. The transdermal route offers the same advantage. Drugs absorbed from suppositories in the lower rectum enter vessels that drain into the inferior vena cava, thus bypassing the liver. However, suppositories tend to move upward in the rectum into a region where veins that lead to the liver predominate. Thus, only about 50% of a rectal dose can be assumed to bypass the liver. 

A Different people have different preferences. You should experiment with both methods and find your own preference. Smoking provides a relatively short, but potentially very intense experience, whereas sublingual absorption provides a substantially longer lasting and somewhat more gentle experience. 

BIOPHARMACEUTICS OF BUCCAL AND SUBLINGUAL ABSORPTION 9.5.1 Principles of Drug Absorption... 

Weinberg, D.S., et al. 1988. Sublingual absorption of selected opioid analgesics. Clin Pharmacol Ther 44 335. 

Florence A.T., and D.A. Attwood. 1998. Buccal and sublingual absorption. In Physicochemical principles of pharmacy. 3rd ed., 392. Basingstoke, UK MacMillan Press. 

Examines surfactant use to accelerate macromolecule input, targeted gastrointestinal delivery, and chemical means of enhancement, as well as promoted buccal and sublingual absorption... 

Chapter 9 Basic Biopharmaceutics of Buccal and Sublingual Absorptions.175... 

Chapter 10 Chemical Enhancers in Buccal and Sublingual Absorptions.203... 

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