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Chemokine structure-function analysis

Structure-function Analysis of Chemokines and the Development of Protein Pharmaceuticals... [Pg.581]

Several lines of evidence favor the monomer as the functional form of the chemokine. Structural analysis conditions require very high concentrations of protein - levels 10- to 1000-fold greater than the protein concentrations needed for biological function, which may not occur in vivo. Also, mutational changes can be made in the primary structure that prevent multimerization and do not significantly affect function (Rajarathnam et al., 1994). Finally, the primary structure of vMIP-II, a virally encoded (human herpesvirus 8 or HHV8) chemokine, resembles that of MIP-la however, vMIP-II fails to dimerize regardless of the pH or protein concentration (personal communication from Barry L. Schweitzer). [Pg.10]

See other pages where Chemokine structure-function analysis is mentioned: [Pg.582]    [Pg.252]    [Pg.358]    [Pg.540]    [Pg.281]    [Pg.301]    [Pg.113]    [Pg.9]    [Pg.22]    [Pg.179]    [Pg.5]    [Pg.151]    [Pg.22]    [Pg.10]    [Pg.192]    [Pg.339]   
See also in sourсe #XX -- [ Pg.581 ]



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