Structure-activity relationships for

This versatile synthetic route has been used extensively with a great variety of phenols and thiophenols to estabUsh structure—activity relationships for thyromimetic activity. Other routes can be summarized as follows (13). 

Structure-activity relationship for gingkolides (lactones) as PAF-antagonists 99PAC1153. 

Finke, P. E., Oates, B., Mills, S. G., MacCoss, M., Malkowitz, L., Springer, M. S., Gould, S. L., DeMartino, J. A., Carella, A. Carver, G., et al. (2001). Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4 synthesis and structure—Activity relationships for l-[7V-(Methyl)-7V-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(7V-(alkyl)-7V-(benzylox-ycarbonyl)amino)piperidin-l-yl)butanes. Bioorg. Med. Chem. Lett. 11 2475-2479. 

Colquhoun D (1998) Binding, gating, affinity and efficacy the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. BrJ Pharmacol 125 924—947... 

Compound optimization, to screen a series of therapeutic diug candidates to find the compounds that are most specific for the target protein and those that cause unintended effects, i.e. improved understanding of the molecular mode of action including structure-activity relationships for on-target versus off-target effects... 

Nagase H, Hamasaki T, Sato T, Kito H, Yoshioka Y, Ose Y (1991) Structure-activity relationships for organotin compounds on the red killifish Oryzias latipes. Applied Organometallic Chemistry, 5(2) 91-97. 

Hirst JD. Nonlinear quantitative structure-activity relationship for the inhibition of dihydrofolate reductase by pyrimidines. J Med Chem 1996 39(18) 3526-32. 

Snyder R, Sangar R, Wang J, Ekins S. Three dimensional quantitative structure activity relationship for CYP2D6 substrates. Quant Struct Act Relationship 2002 21 357-68. 

Ethell BT, Ekins S, Wang J, Burchell B. Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9. Drug Metab Dispos 2002 30 734-8. 

Soffers AEMF, Ploeman JHTM, Moonen MJH, Wobbes T, van Ommen B, Vervoort J, et al. Regioselectivity and quantitative structure-activity relationships for the conjugation of a series of fluoronitrobenzenes by purified glutathione S -transferase enzymes from rat and man. Chem Res Toxicol 1996 9 638-46. 

Zhang S, Yang X, Coburn RA and Morris ME. Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein. Biochem Pharmacol 2005 70 627-39. 

Doucette, W.J. (2003) Quantitative Structure-Activity Relationships for Predicting SoU-Sediment Sorption Coefficients for Organic Chemicals. Environmental Toxicology and Chemistry, 22(8), 1771-1788. 

Since the causative organism of leprosy, one of the world s six major diseases, Mycobacterium leprae, is closely related to Mycobacterium tuberculosis, thio-semicarbazones have also been used as second-line drugs in the chemotherapy of leprosy [38]. The most widely used in leprosy treatment has been thiacetazone, and structure-activity relationships for it are similar to those observed for antitubercular thiosemicarbazones [39, 40]. 

The structure/activity relationships for the methisazone, 3a, derivatives against adenoviruses and poxviruses have been shown to be similar [78]. Pearson and Zimmerman [79] demonstrated that all three types of polioviruses are inhibited by 2-acetylpyridine JV-dibutylthiosemicarbazone, which is similar to 3a, by blocking viral RNA synthesis. A 3-substituted triazinoindole derivative of isatin was effective against several strains of rhinovirus in tissue culture the mechanism of action is unknown [80]. 

TABLE 2. Structure-activity relationship for piperidine analogs... 

Lemus, R. H. Skibo, E. B. Design of pyritnido[4.5-s quinazoline-based anthraquinone mimics, structure-activity relationship for quinone methide formation and the influence of internal hydrogen bonds on quinone methide fate. J. Org. Chem. 1992, 57, 5649-5660. 

Xing, C. Skibo, E. B. Dorr, R. T. Aziridinyl quinone antitumor agents based on indoles and cyclopent[6]indoles structure-activity relationships for cytotoxicity and antitumor activity. J. Med. Chem. 2001, 44, 3545-3562. 

Johannsen and colleagues (1977) report dermal LD50 values for rabbits at levels of >3,700 mg/kg for a group of triaryl phosphates, >5,000 mg/kg for dibutyl phenyl phosphate, 5,000 mg/kg for both asymmetrical and symmetrical triaryls, and >3,100 mg/kg for tributyl phosphate. This study looked at structural activity relationships for the organophosphate esters. 

Bruns RF, Fergus JH, Coughenour LL, Courtland GG, Pugsley TA, Dodd JH, Tinney JF. Structure-activity relationships for enhancement of adenosine Ai receptor binding by 2-amino-3-benzoylthiophenes. Mol Pharmacol 1990 38 950-958. 

Dewhirst FE. Structure/activity relationship for inhibition of prostaglandin cyclooxygenase by phenolic compounds. Prostaglandins 1980 20 209-222. 

Verhaar HJM, vanLeeuwen CJ, Hermens JLM (1992) Classifying environmental pollutants. 1. Structure-activity relationships for prediction of aquatic toxicity. Chemosphere 25 471—491... 

S. Leonard, and D. R. Thakker. Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines, J. Med. Chem. 2002, 45, 2857-2866... 

Norinder, U., Hogberg, T., A quantitative structure-activity relationship for some dopamine D2 antagonists of benzamide type, Acta Pharm. Nord. 1992, 4, 73-78. 

The structure-activity relationships for thiourea derivatives have been investigated as vanilloid receptor antagonist,216 220 and mast cell leukotriene release, etc.221 224... 

Atkinson, R. (1987) A structure-activity relationship for the estimation of the rate constants for the gas phase reactions of OH radicals with organic compounds. Int. J. Chem. Kinetics 19, 790-828. 

Mill, T. (1989) Structure-activity relationships for photooxidation processes in the environment. Environ. Toxicol. Chem. 8, 31—45. 

Govers, H., Ruepert, C., Aiking, H. (1984) Quantitative structure-activity relationships for polycyclic aromatic hydrocarbons Correlation between molecular connectivity, physico-chemical properties, bioconcentration and toxicity in Daphnia pulex. Chemosphere 13, 227-236. 

Shier WT, Shier AC, Xie W and Mirocha CJ. 2001. Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins. Toxicon 39 (9) 1435—1438. 

The above findings are supported in the other studies of the inhibitory effects of flavonoids on iron-stimulated lipid peroxidation. Quercetin was found to be an inhibitor of iron-stimulated hepatic microsomal lipid peroxidation (/50 = 200 pmol I ) [134]. Flavonoids eriodictyol, luteolin, quercetin, and taxifolin inhibited ascorbate and ferrous ion-stimulated MDA formation and oxidative stress (measured by fluorescence of 2,7,-dichlorodihydro-fluorescein) in cultured retinal cells [135]. It should be mentioned that in recent work Heijnen et al. [136] revised the structure activity relationship for the protective effects of flavonoids against lipid peroxidation. 

---