Stress response element

Khachigian LM, Resnick N, Gimbrone MA Jr, Collins T. Nuclear factor-KB interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. / Clin Invest. 1995 96 1169-1175. 

Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey CF Jr, Gimbron MA. Platelet-derived growth factor B chain promoter contains cis-acting fluid shear-stress responsive element. Proc Natl Acad Sci USA. 1993 90 7908. 

Martinez-Pastor, M.T., G. Marchler, C. Schuller, A. Marchler-Bauer, H. Ruis, and F. Estruch (1996). The Saccharomyces cerevisiae zinc-finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress-response element (STRE). EMBO J. 15 2227-2235. 

ERSE Endoplasmic reticulum (ER) stress-response element... 

P450 8A1 is constitutively expressed in human endothelial cells . The human CYP8A1 gene (chromosome 20) has 10 exons and has consensus sequences for Spl, AP-2, an interferon--/ response element, GATA NF, B, a CACCC box, glucocorticoid receptor, and a shear stress responsive element (GAGACC) . Whether or not all of these are functional and how they interact to maintain constitutive expression is not well understood yet. 

NOS III is found to be constitutively expressed in endothelial cells and some other cell types (see below). Some mechanisms that also regulate the expression of the NOS III gene have been described. Shear stress produced by the flowing blood not only increases endothelial NO release acutely (Lamontagne etal., 1992) but also up-regulates NOS III expression (Nishida et al., 1992). A putative shear stress-responsive element has been described... 

Resnick, N., Collins, T., Atkinson, W., Bonthron, D. T., Dewey, C. F., Jr., and Gimbrone, M. A., Jr. (1993). Platelet-derived growth factor (3 chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc. Natl. Acad. Sci. U.S.A. 90, 4591-4595. 

Moskvina, E. et al (1998) A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements. Yeast, 14 (11), 1041-1050. 

In plants, DREB/ERF and AP2/ERF subfamily of ethylene-responsive element (GCC box)-binding transcription factors function in the regulation of abiotic stress responses and regulate disease resistance. AP2/ERF members are downstream components of both ethylene and JA signaling pathways, and are key to the... 

Regulation of catalase expression in eukaryotes takes place as part of a generalized response mechanism. In yeast, promoter elements of the peroxisomal catalase CTA-1 respond to glucose repression and activation by fatty acids as part of organelle synthesis. The cytosolic catalase CTT-1 responds as part of a generalized stress response to starvation, heat, high osmolarity, and H2O2, and there is even evidence of translational control mediated by heme availability 26). 

Silvestre J, Fernandez AG, Palacios JN (1999) Effects of rolipram on the elevated plus-maze test in rats a preliminary study. J Psychopharmacol 13 274-277 Sousa N, Lukoyanov NV, Madeira MD, Almeida OF, Paula-Barbosa MM (2000) Reorganization of the morphology of hippocampal neurites and synapsed after stress-induced damage correlates with behavioral improvements. Neuroscience 97 253-266 Stanciu M, Radulovic J, Spiess J (2001) Phosphorylated cAMP response element binding protein in the mouse brain after fear conditioning relationship to Fos production. Mol Brain Res 94 15-24... 

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