Streptomycin dosage

Children Infants A syndrome of apparent CNS depression, characterized by stupor and flaccidity, occasionally coma, and deep respiratory depression, has been reported in young infants in whom streptomycin dosage had exceed the recommended limits. Do not giye infants streptomycin in excess of the recommended dosage. 

Sreptomycin. Streptomycin is usually administered daily as a single IM injection. The preferred site is the upper outer quadrant of the buttock or die midlateral thigh. The deltoid area is used only if die area is well developed. In patients 60 years of age or older, the dosage is reduced because of die risk of increased toxicity. 

Streptomycin usually is administered daily as a single IM injection. Give a total dose of less than 120 g over the course of therapy unless there are no other therapeutic options. In patients older than 60 years of age, use a reduced dosage. The total period of drug treatment for TB is a minimum of 1 year. 

Streptomycin is mainly used as a second-line agent for treatment of tuberculosis. The dosage is 0.5-1 g/d (7.5-15 mg/kg/d for children), which is given intramuscularly or intravenously. It should be used only in combination with other agents to prevent emergence of resistance. See Chapter 47 for additional information regarding the use of streptomycin in mycobacterial infections. 

Strains of multidrug-resistant Mycobacterium tuberculosis, including streptomycin-resistant strains, are usually susceptible to amikacin. Kanamycin-resistant strains may be cross-resistant to amikacin. The dosage of amikacin for tuberculosis is... 

Administration of streptomycin intramuscularly is the method of choice for treating systemic infections. Oral forms of streptomycin or dihydrostreptomycin, frequently combined with sulfonamide drugs and other compounds, are also used in animals for treatment of enteric infections. In addition, streptomycin is used as a feed additive for growth promotion purposes. In some countries, the combination of streptomycin with procaine penicillin is used as an initial nonspecific therapy in farm animals, and in intramammary applications for treatment of mastitis. Intramuscular dosages are in the range 5-10 mg/kg bw, while oral dosages are 20 mg/kg bw. Dihydrostreptomycin is also used in veterinary medicine in intramammary and topical treatments. 

P Edder, A Cominoli, C Corvi. Dosage de residus de streptomycine dans le miel par HPLC avec post-derivatisation et detection fluorimetrique. Trav Chim Aliment Hyg 89 369-382, 1998. 

This case concerns a chronic E. coli infection of the urinary tract in a 65 year old male that has been present for 12 years and induced a constant, considerable impairment to his overall well-being, and led to attacks of fever and hypochromic anemia.. . . Tests of the infection revealed that the bacteria were nearly completely resistant to Sulfonamide, penicillin, Streptomycin, and Aureomycin.. .. The response to Terramycin, however, was astonishing.. . . Unfortunately, we only had sufficient supplies for two days... . We would be most appreciative if you [Boehringer] could supply us with additional dosages in such instances.37... 

Children Preferred choices Streptomycin, 15 mg kg IM twice daily (maximum daily dose, 2g) Gentamicin, 2.5 mg kg IM or IV three times daily Alternative choices Doxycycline If >45kg, give adult dosage If <45kg, give 2.2mg kg twice daily (maximum, 200mg d- ) Ciprofloxacin, 15 mg kg IV twice daily Chloramphenicol, 25 mg kg IV four times daily" ... 

Sterilized mash is inoculated with a pure culture of Streptomyces griseus and aerated under aseptic conditions for several days at 25° to 30° C. The broth is filtered and activated carbon is added to the clear filtrate to adsorb the streptomycin. The carbon dosage must be closely controlled as an insufficient amount results in incomplete adsorption, and an excess of carbon reduces the yield by elution. The carbon is separated by filtration and washed with alcohol to remove loosely held impurities, after which the streptomycin is eluted from the carbon with acidified methanol. The eluate is neutralized and evaporated at reduced pressure under carefully controlled conditions to prevent decomposition of the streptomycin. At this point, the streptomycin is 25 to 30% pure and a number of subsequent steps are required to obtain a final product free from all toxic impurities. In some operations, a subsequent purification with activated carbon is provided under conditions in which the impurities are adsorbed and not the streptomycin. 

Sulfonamides are of value in treating infections due to Nocardia spp. Sulfisoxazole or sulfadiazine may be given in dosages of 6-8 g daily and is continued for several months after all manifestations have resolved. The administration of a sulfonamide together with a second antibiotic has been recommended, especially for advanced cases, and ampicillin, erythromycin, streptomycin... 

The interaction between doxycycline and rifampicin is established and of clinical importance. Monitor the effects of concurrent use and increase the doxycycline dosage as necessary. No clinically important adverse interaction appears to occur between doxycycline and streptomycin. 

Streptomycin (SM) is an aminoglycoside antibiotic discovered in 1943 and used in tuberculosis treatment since 1948 (Winston, 2012 Schatz, 1993). It is used in injectable form with a dosage of 15 mg/kg body weight (Hmama, 2013) (Figure 11.6). 

Assay Technique. Serum levels of viomycin, under certain dosage schedules, run rather high. It may be indicated that preliminary dilution of serum samples should be made. The mode of performance and interpretation should parallel that used for streptomycin (Section IV,2). 

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