Tuberculosis, treatment

Administer pyridoxine (vitamin Be) 25 to 50 mg daily or 50 to 100 mg twice weekly to all HIV-infected patients who are undergoing tuberculosis treatment with isoniazid to reduce the occurrence of isoniazid-induced side effects in the central and peripheral nervous system. 

Because the MMWRs most recent recommendations for the use of antiretroviral therapy strongly advise against interruptions of therapy, and because alternative tuberculosis treatments that do not contain rifampin are available, previous antituberculosis therapy options that involved stopping protease inhibitor therapy to allow the use of rifampin are no longer recommended. 

Tuberculosis Treatment of tuberculosis in combination with other active agents. It is most commonly used in patients with multi-drug resistant tuberculosis (MDR-TB) or in situations when therapy with isoniazid and rifampin is not possible because of a combination of resistance and intolerance. 

The three basic concepts in tuberculosis treatment are as follows (1) Regimens must contain multiple drugs to which the organism is susceptible. (2) Drugs must be taken regularly. (3) Drug therapy must con-... 

Rifapentine Oral long-acting analog of rifampin that may given once weekly in the continuation phase of tuberculosis treatment ... 

Isoniazid Inhibits synthesis of mycolic acids, an essential component of mycobacterial cell walls Bactericidal activity against susceptible strains of M tuberculosis First-line agent for tuberculosis treatment of latent infection less active against other mycobacteria Oral, IV hepatic clearance (half-life 1 h) reduces levels of phenytoin Toxicity Flepatotoxic, peripheral neuropathy (give pyridoxine to prevent)... 

One such accident occurred in the 1950s, when scientists searching for a tuberculosis treatment observed that the drug iproniazid caused mood elevation. Since there were few treatments for depression, the findings were exciting. 

While the sulfone was inactive as an inhibitor of gastric acid secretion, the sulfoxide, H 83/69, was found to be a very potent inhibitor of acid secretion. Pharmacokinetic studies of H 124/26 conducted at Abbott Laboratories indicated a rapid formation of two main metabolites, the sulfoxide H 83/69 and the corresponding sulfone [9]. However, there followed further setbacks, initially when H 124/26 turned out to be known from a Hungarian patent aimed at tuberculosis treatment. Moreover, both compounds (H 124/26 and H 83/69) were found to be toxic, particularly affecting the thyroid gland. Despite this, H 83/69 - which became known as timoprazole - proved to be a breakthrough, mainly because of a number of key observations that were made about the compound. 

Grosset, J. Current prohlems with tuberculosis treatment. 9. 

E. F. Torrey and J. Miller, Can psychiatry learn from tuberculosis treatment Psychiatric Services, 50 1389 (November), 1999, emphasis added. 

Thrombolytic agents a need for improvement Thyroid preparations Trace minerals essential for health Traveler s diarrhea prevention of Tuberculosis treatment of Upper respiratory tract infection treatment of Urinary tract infections treatment of Uveitis management of Vaginal candidiasis treatment of Vasodilators effects on cardiac output (CO)... 

The dose of rifampin for tuberculosis treatment in adults is 600 mg daily, given either 1 hour before or 2 hours after a meal. Children should receive 10 mg/kg given in the same way. Rifampin should never be used alone for the treatment of tuberculosis because of the rapidity with which resistance may develop. 

Raistrick D, Hay A, Wolff K. Methadone maintenance and tuberculosis treatment EMJ... 

Rifampicin (rifampin) lowers the serum levels of theophylline, but rifabutin appears to have little effect. Isoniazid may decrease or increase theophylline clearance and may increase theophylline levels. An isolated report describes theophylline toxicity one month after a patient started to take theophyUine with isoniazid. Isoniazid and rifampicin increased theophylline clearance during the initial few days of tuberculosis treatment in one study, but there is some evidence that it decreases it within 4 weeks in another. 

Designing and testing single tablet for tuberculosis treatment through electrospinninj... 

The action mechanism, pharmacology, and the side effects of some drugs used in tuberculosis treatment are described below. 

Despite the activity of rifampicin in tuberculosis treatment, it shows many side effects. It may cause gastrointestinal upset and hepatotoxicity. 

Streptomycin (SM) is an aminoglycoside antibiotic discovered in 1943 and used in tuberculosis treatment since 1948 (Winston, 2012 Schatz, 1993). It is used in injectable form with a dosage of 15 mg/kg body weight (Hmama, 2013) (Figure 11.6). 

Dos Santos, J.L., Chin, C.M., de Vizioli, E.O., 2012. Health interventions to improve the medication efficacy in tuberculosis treatment. In Cardona, P.-J. (Ed.), Understanding Tuberculosis - Global Experiences and Innovative Approaches to the Diagnosis. InTech, Rijeka, Croatia, pp. 527—553. Available from http //dx.doi.org/10.5772/1483. 

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